Most common causes of neonatal cholestasis

Diagnosis	Proportion of young infants with conjugated hyperbilirubinemia
Extrahepatic biliary atresia	25% (range 2 to 55%)
Idiopathic neonatal hepatitis	25% (range 4 to 45%)
Infectious hepatitis (eg, cytomegalovirus)	11% (range 3 to 38%)
Parenteral nutrition-associated	6% (range 7 to 30%)
Metabolic disease (eg, galactosemia, tyrosinemia)	4%
Alpha-1 antitrypsin deficiency	4%
Alagille syndrome	1%
Progressive familial intrahepatic cholestasis	1%

The percentages shown here are based upon a systematic review of 17 studies encompassing 1692 infants.Most but not all of the studies were from resource-rich countries. The proportion of infants in each category varied substantially across the studies, likely due to differences in infectious diseases in the population as well as the methods used to make the diagnoses.

Data from: Gottesman LE, Del Vecchio MT, Aronoff SC. Etiologies of conjugated hyperbilirubinemia in infancy: A systematic review of 1692 subjects. BMC Pediatrics 2015; 15:192.

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Most common causes of neonatal cholestasis