Importance of TPO activity on bone marrow progenitor cells

Bone marrow progenitor cells (±SD) in normal, wild-type (WT), thrombopoietin-deficient (TPO -/-), and c-Mpl-deficient (MPL -/-) mice. GM-CFC (GM), E-BFC, Meg-CFC (Meg), mixed colonies (Mix-CFC) with erythroid component (E Mix), erythroid and megakaryocytic components (E/M Mix), or megakaryocytic with nonerythroid components (M-Mix) are markedly reduced in the absence of TPO or its receptor.