Diagnostic approach in suspected rickets

Rickets is suggested by typical clinical signs and elevated alkaline phosphatase activity in a child who has normal kidney and liver function. Calcipenic rickets is sometimes termed "hypocalcemic rickets," but this term is not completely accurate, because serum Ca is not always low in this disorder.

PTH: parathyroid hormone; Pi: inorganic phosphorus; Ca: calcium.

* The diagnosis of calcipenic rickets should be confirmed by monitoring response to therapy.

¶ In phosphopenic rickets, serum Pi is often very low.

Δ Hypophosphatasia is accompanied by low serum alkaline phosphatase activity.

Graphic 79880 Version 8.0

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