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TNM staging system for lung cancer (seventh edition)

TNM staging system for lung cancer (seventh edition)
Primary tumor (T)
T1 Tumor ≤3 cm diameter, surrounded by lung or visceral pleura, without invasion more proximal than lobar bronchus*
T1a Tumor ≤2 cm in diameter
T1b Tumor >2 cm but ≤3 cm in diameter
T2 Tumor >3 cm but ≤7 cm, or tumor with any of the following features:
Involves main bronchus, ≥2 cm distal to carina
Invades visceral pleura
Associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung
T2a Tumor >3 cm but ≤5 cm
T2b Tumor >5 cm but ≤7 cm
T3 Tumor >7 cm or any of the following:
Directly invades any of the following: chest wall, diaphragm, phrenic nerve, mediastinal pleura, parietal pericardium, main bronchus <2 cm from carina (without involvement of carina)
Atelectasis or obstructive pneumonitis of the entire lung
Separate tumor nodules in the same lobe
T4 Tumor of any size that invades the mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, or with separate tumor nodules in a different ipsilateral lobe
Regional lymph nodes (N)
N0 No regional lymph node metastases
N1 Metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension
N2 Metastasis in ipsilateral mediastinal and/or subcarinal lymph node(s)
N3 Metastasis in contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s)
Distant metastasis (M)
M0 No distant metastasis
M1 Distant metastasis
M1a Separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural or pericardial effusion
M1b Distant metastasis (in extrathoracic organs)
Stage groupings
Stage IA T1a-T1b N0 M0
Stage IB T2a N0 M0
Stage IIA T1a,T1b,T2a N1 M0
T2b N0 M0
Stage IIB T2b N1 M0
T3 N0 M0
Stage IIIA T1a,T1b,T2a,T2b N2 M0
T3 N1,N2 M0
T4 N0,N1 M0
Stage IIIB T4 N2 M0
Any T N3 M0
Stage IV Any T Any N M1a or M1b
* The uncommon superficial spreading tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a.
Adapted from: Goldstraw P, Crowley J, Chansky K, et al. The IASLC Lung Cancer Staging Project: Proposals for the revision of the TNM stage groups in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2:706.
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