Major adverse effects of methotrexate*

Bone marrow toxicity

Neutropenia (most common, usually reversible)

Thrombocytopenia (dose related, usually reversible)

Anemia (rare)

Hepatic toxicity

Cirrhosis & fibrosis

Pulmonary toxicity

Opportunistic infections

PCP, CMV, Herpes zoster, fungal, mycobacterial, etc

Noninfectious conditions

Hypersensitivity pneumonitis

Organizing pneumonia (previously called bronchiolitis obliterans with organizing pneumonia or BOOP)

Acute lung injury (noncardiogenic pulmonary edema)

Pulmonary fibrosis

Asthma/hyperreactive airways disease

Pleuritis and/or pleural effusion

Miscellaneous

Oligospermia

Teratogenicity

Malignancy

PCP: Pneumocystis pneumonia; CMV: cytomegalovirus.
* Major adverse effects are defined as potentially life-threatening (incidence <1 percent) or requiring withdrawal of treatment (incidence 3 to 15 percent).

Graphic 80229 Version 4.0

خرید پکیج

Major adverse effects of methotrexate*