Version July 2025
| Category based on conventional use | Class | Subclass | Drugs |
| Multipurpose analgesics | Glucocorticoids | – | Dexamethasone, prednisone, methylprednisone |
| Antidepressants | Tricyclic | Amitriptyline, desipramine, nortriptyline | |
| SNRIs | Duloxetine, minalcipran, desvenlafaxine | ||
| SSRIs | Paroxetine, citalopram | ||
| Other | Buproprion | ||
| Alpha-2 adrenergic agonists | – | Tizanidine, clonidine | |
| Cannabinoids | – | Dronabinol, nabilone, nabiximols | |
| Topical analgesics | – | Local anesthetics, lidocaine, capsaicin, tricyclic antidepressants, NSAIDs, others | |
| Botulinum toxin injections | – | – | |
| Used for neuropathic pain | All multipurpose analgesics | Refer to above | Refer to above |
| Antiseizure medications | – | Gabapentin, pregabalin, valproate, phenytoin, carbamazepine, oxcarbazepine, topiramate, lamotrigine | |
| Sodium channel blockers | Sodium channel modulator | Lacosamide | |
| Sodium channel blocker | Mexiletine, intravenous lidocaine | ||
| NMDA receptor antagonists | – | Ketamine, memantine, dextromethorphan, amantadine | |
| GABA agonists | GABAa agonists | Clonazepam | |
| GABAb agonists | Baclofen | ||
| Used for bone pain | Osteoclast inhibitors | Bisphosphonates | Pamidronate, zolendronate, ibandronate |
| – | Calcitonin | ||
| RANKL inhibitor | Denosumab | ||
| Radiopharmaceuticals | – | Strontium-89, samarium-153, radium-223 | |
| NSAIDs, glucocorticoids | – | – | |
| Used for bowel obstruction | Anticholinergic drugs | – | Scopolamine, atropine, glycopyrrolate |
| Somatostatin analog | – | Octreotide | |
| Glucocorticoids | – | – |
