Antibiotic dosing for continuous or postcoital prophylaxis of recurrent cystitis in women

Antibiotic	Dosing for continuous prophylaxis	Dosing for postcoital prophylaxis
Nitrofurantoin	50 mg once daily OR 100 mg once daily	50 mg once OR 100 mg once
Trimethoprim-sulfamethoxazole	40 mg/200 mg (half a single-strength tablet) once daily OR 40 mg/200 mg (half a single-strength tablet) three times weekly	40 mg/200 mg (half a single-strength tablet) once OR 80 mg/400 mg (single-strength tablet) once
Trimethoprim	100 mg once daily	100 mg once
Cephalexin	125 mg once daily OR 250 mg once daily	250 mg once
Cefaclor	250 mg once daily
Fosfomycin	3 g every 7 to 10 days*

The choice of antibiotic should be based upon the susceptibility patterns of the strains causing the patient's previous cystitis, history of drug allergies, and potential for interactions with other medications. We mainly choose between nitrofurantoin and trimethoprim-sulfamethoxazole, if appropriate.

UTI: urinary tract infection.
* The optimal dosing interval of fosfomycin is uncertain; in efficacy trials, the dose was administered every 7 to 10 days. However, some experts have used shorter intervals (eg, every three to four days) with the hypothesis that they result in more days with detectable drug levels, which would approximate prophylaxis dosing with other agents.

Graphic 80898 Version 3.0

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Antibiotic dosing for continuous or postcoital prophylaxis of recurrent cystitis in women