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تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Chemotherapy response in different histologies of salivary gland tumors

Chemotherapy response in different histologies of salivary gland tumors
Agent/regimen Histology
Adenoid cystic cancer Mucoepidermoid cancer Adenocarcinoma
Number of responses/total number of patients (%) Number of responses/total number of patients (%) Number of responses/total number of patients (%)
Cisplatin[1,2] 2/32 (6) 1/5 0/5
Vinorelbine[3] 2/13 (15) - 2/5
Mitoxantrone[4,5] 5/50 (10) - -
Epirubicin[6] 2/20 (10) - -
Methotrexate[7] - 2/5 (40) -
Paclitaxel[8] 0/14 3/14 (21) 5/17 (29)
CAP or CAP/FU[7,9-14] 12/43 (28) 5/6 (83) 23/37 (62)
Cisplatin/anthracycline ± FU[15-18] 6/19 (32) 1/4 8/14 (57)
Cyclophosphamide/doxorubicin[7,19] 2/6 0/6 1/1
Cisplatin/MTX/bleomycin[7,19] 0/3 2/3 (66) -
Cisplatin/FU[20] 0/11 - -
Cisplatin/vinorelbine[3] 4/9 (44) - 1/5
Cisplatin/doxorubicin/bleomycin[2] 3/9 (33) - -
Carboplatin/paclitaxel[21,22] 2/10 (20) - 1/1
Cisplatin/gemcitabine[23] 2/10 (20) 1/4 (25) 3/8 (38)
CAP: cyclophosphamide, doxorubicin, cisplatin; FU: fluorouracil; MTX: methotrexate.
References:
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  17. Tsukuda M, Kokatsu T, Ito K, et al. Chemotherapy for recurrent adeno- and adenoidcystic carcinomas in the head and neck. J Cancer Res Clin Oncol 1993; 119:756.
  18. White JD, Junor EJ, McGarva J, et al. Adenocarcinoma of the salivary gland? A chemo-sensitive disease. Clin Oncol 2004; 16:159.
  19. Posner MR, Ervin TJ, Weichselbaum RR, et al. Chemotherapy of advanced salivary gland neoplasms. Cancer 1982; 50:2261.
  20. Hill ME, Constenla DO, A'Hern RP, et al. Cisplatin and 5-fluorouracil for symptom control in advanced salivary adenoid cystic carcinoma. Oral Oncol 1997; 33:275.
  21. Ruzich JC, Ciesla MC, Clark JI. Response to paclitaxel and carboplatin in metastatic salivary gland cancer: a case report. Head Neck 2002; 24:406.
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  23. Laurie SA, Siu LL, Winquist E, et al. A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer: a trial of the NCIC Clinical Trials Group. Cancer 2010; 116:362.
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