Version June 2024
| Definitions |
| Chronic hepatitis B |
| Chronic necroinflammatory disease of the liver caused by persistent infection with hepatitis B virus. Chronic hepatitis B can be subdivided into HBeAg-positive and HBeAg-negative chronic hepatitis B. |
| Inactive HBsAg carrier state |
| Persistent HBV infection of the liver without significant, ongoing necroinflammatory disease. |
| Resolved hepatitis B |
| Previous HBV infection without further virological, biochemical, or histological evidence of active virus infection or disease. |
| Acute exacerbation or flare of hepatitis B |
| Intermittent elevations of aminotransferase activity to more than 10 times the upper limit of normal and more than twice the baseline value. |
| Reactivation of hepatitis B |
| Reappearance of active necroinflammatory disease of the liver in a person known to have the inactive HBsAg carrier state or resolved hepatitis B. |
| HBeAg clearance |
| Loss of HBeAg in a person who was previously HBeAg positive. |
| HBeAg seroconversion |
| Loss of HBeAg and detection of anti-HBe. |
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