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TNM staging system for diffuse malignant pleural mesothelioma

TNM staging system for diffuse malignant pleural mesothelioma
Primary tumor (T)
TX Primary tumor cannot be assessed
T0 No evidence of primary tumor
T1 Tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement
T1a No involvement of the visceral pleura
T1b Tumor also involving the visceral pleura
T2 Tumor involving each of the ipsilateral pleural surface (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following:
Involvement of diaphragmatic muscle
Extension of tumor from visceral pleura into the underlying pulmonary parenchyma
T3 Locally advanced but potentially resectable tumor
Tumor involving all of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following:
Involvement of the endothoracic fascia
Extension into the mediastinal fat
Solitary, completely resectable focus of tumor extending into the soft tissues of the chest wall
Nontransmural involvement of the pericardium
T4 Locally advanced technically unresectable tumor
Tumor involving all of the ipsilateral pleural surfaces (parietal, mediastinal, diaphragmatic, and visceral pleura) with at least one of the following:
Diffuse extension or multifocal masses of tumor in the chest wall, with or without associated rib destruction
Direct transdiaphragmatic extension of tumor to the peritoneum
Direct extension of tumor to the contralateral pleura
Direct extension of tumor to mediastinal organs
Direct extension of tumor into the spine
Tumor extending through to the internal surface of the pericardium with or without a pericardial effusion or tumor involving the myocardium
Regional lymph nodes (N)
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastases
N1 Metastases in the ipsilateral bronchopulmonary or hilar lymph nodes
N2 Metastases in the subcarinal or the ipsilateral mediastinal lymph nodes including the ipsilateral internal mammary and peridiaphragmatic nodes
N3 Metastases in the contralateral mediastinal, contralateral internal mammary, ipsilateral or contralateral supraclavicular lymph nodes
Distant metastasis (M)
M0 No distant metastasis
MI Distant metastasis present
Anatomic stage/prognostic groups
Stage I T1 N0 M0
Stage IA T1a N0 M0
Stage IB T1b N0 M0
Stage II T2 N0 M0
Stage III T1, T2 N1 M0
T1, T2 N2 M0
T3 N0, N1, N2 M0
Stage IV T4 Any N M0
Any T N3 M0
Any T Any N M1
Note: cTNM is the clinical classification, pTNM is the pathologic classification.
Used with the permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original source for this material is the AJCC Cancer Staging Manual, Seventh Edition (2010) published by Springer New York, Inc.
Graphic 81665 Version 13.0

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