Megakaryocyte response to changes in platelet count

The physiologic response of bone marrow megakaryocytes in mice made acutely thrombocytopenic by the injection of antiplatelet antibody (Panel A) or made thrombocytotic by the transfusion of platelets (Panel C) and compared with untreated mice (Panel B) (x16). The number, size, and nuclear lobulation of bone marrow megakaryocytes increased during thrombocytopenia and decreased during thrombocytosis when compared with normal animals.