Antifungal treatment recommendations for nonmeningeal cryptococcosis

Patient group	Initial antifungal regimen	Duration
Immunosuppressed patients and immunocompetent patients with mild-to-moderate pulmonary cryptococcosis	Fluconazole (400 mg per day)	6 to 12 months
Immunosuppressed patients* and immunocompetent patients with severe pulmonary cryptococcosis	Same as CNS disease	12 months
Patients with nonmeningeal, nonpulmonary cryptococcosis
Patients with cryptococcemia	Same as CNS disease	12 months
Patients for whom CNS disease has been ruled out with no fungemia, with a single site of infection, and with no immunosuppressive risk factors	Fluconazole 400 mg per day	6 to 12 months

CNS: central nervous system.
* Should directly rule out CNS disease with lumbar puncture.

Reproduced with permission from: Perfect JR, Disnukes WE, Dromer F, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:291. Copyright © 2010 University of Chicago Press.

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Antifungal treatment recommendations for nonmeningeal cryptococcosis