Grading severity of hand-foot skin reaction

Grade	Symptoms
Grade 1	Numbness, dysesthesia, paresthesia, tingling, painless swelling, erythema or discomfort in the hands and feet, not affecting the patient's activities of daily living
Grade 2	Painful erythema, swelling of the hands or feet, and/or discomfort affecting the patient's activities of daily living
Grade 3	Peeling, blistering, erosions, or severe pain of the hands and feet, or severe discomfort that causes the patient to be unable to work or perform activities of daily living

Modified from: Lacouture ME, Wu S, Robert C, et al. Evolving strategies for the management of hand-foot skin reaction associated with the multi-targeted kinase inhibitors sorafenib and sunitinib. The Oncologist 2008; 13:1001.

Graphic 82460 Version 2.0

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Grading severity of hand-foot skin reaction