Version June 2024
| 70% of joint erosions detectable by radiograph of hands and feet occur in the first 2 years of disease |
| At 20 years, over 60% of patients with RA belong to functional class III (significantly impaired, self-caring, using aids, requiring joint replacements) or class IV (loss of independence requiring daily care) |
| Increased incidence of: |
| Infections |
| Cardiovascular disease |
| Lymphomas |
| Life expectancy of RA less than age/sex-matched control populations, especially in patients with one or more of the following: |
| Polyarticular disease |
| Systemic extraarticular disease |
| Persistent disease activity (high ESR, CRP) |
| Seropositivity for ACPA and rheumatoid factors |
| HLA-DR beta chain "shared epitope," especially if bialleic |
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