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World Health Organization (WHO) classification of germ cell tumors of the central nervous system

World Health Organization (WHO) classification of germ cell tumors of the central nervous system
Tumor type Definition
Germinoma A malignant germ cell tumor composed of cells resembling primordial germ cells
Mature teratoma A germ cell tumor composed solely of fully differentiated, adult-type somatic tissue components that recapitulate the differentiating potential of the ectoderm, endoderm, and mesoderm
Immature teratoma A germ cell tumor containing incompletely differentiated, fetal-like somatic tissue components that recapitulate the differentiating potential of the ectoderm, endoderm, and mesoderm; mature elements may be admixed
Teratoma with somatic-type malignancy A germ cell tumor of mature or immature teratomatous type that develops a distinct secondary component resembling a somatic-type malignant neoplasm (eg, sarcoma or carcinoma) as seen in other organs and tissues
Embryonal carcinoma A malignant germ cell tumor composed of large epithelioid cells resembling those of the embryonic germ disc
Yolk sac tumor A malignant germ cell tumor that differentiates to resemble extraembryonic structures, including the yolk sac, allantois, and extraembryonic mesenchyme
Choriocarcinoma A malignant germ cell tumor that differentiates to resemble the trophoblastic cells of the extraembryonic chorion, including syncytiotrophoblastic and cytotrophoblastic elements
Mixed germ cell tumors Malignant germ cell tumors harboring at least 2 germ cell tumor subtypes in any combination
Adapted from Central Nervous System Tumours: WHO Classification of Tumours, 5th ed, Vol. 6, WHO Classification of Tumours Editorial Board, Germ cell tumours, page 383. Copyright © 2021 International Agency for Research on Cancer. https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/Central-Nervous-System-Tumours-2021 (Accessed on April 26, 2024).
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