Psoralens used with ultraviolet A light therapy (PUVA) for psoriasis and vitiligo

Drug	Brand or generic	Trade name(s)	Manufacturer	Preparation	Suggested initial dose* (adult)
Methoxsalen (8-methoxypsoralen, 8-MOP)	Brand	Oxsoralen-Ultra	Valeant Pharmaceuticals	10 mg liquid filled soft-gelatin capsule	0.4 mg/kg orally 1 hour prior to UVA^¶
	Generic	N/A	Oceanside Pharmaceuticals (a division of Valeant Pharmaceuticals)	10 mg liquid filled soft-gelatin capsule	0.4 mg/kg orally 1 hour prior to UVA^¶
	Generic	N/A	Strides Pharmaceuticals	10 mg liquid filled soft-gelatin capsule	0.4 mg/kg orally 1 hour prior to UVA^¶
	Brand^Δ	8-MOP	Valeant Pharmaceuticals	10 mg hard-gelatin capsule	0.6 mg/kg orally 2 hours prior to UVA^¶
	Brand	Oxsoralen (lotion)	Valeant Pharmaceuticals	10 mg/mL lotion (in 71% ethanol)	Diluted 1:10 with ethanol to deliver 0.1% strength; applied to affected area according to PUVA protocol (refer to text)
Trioxsalen (4,5',8-trimethylpsoralen, trioxysalen, TMP) Not available in the United States	Brand	Trisoralen (inactive trade name)	ICN pharmaceuticals; Valeant (former United States manufacturer)	5 mg	0.6 mg/kg orally 2 hours prior to UVA
Bergapten^◊ (5-methoxypsoralen, 5-MOP)^[1] Not available in the United States	Brand	Pentaderm, Psoraderm 5, Geralen	May be available in some countries as an unlicensed product	20 mg tablet^◊	1.2 mg/kg orally 2 hours prior to UVA

* Doses must be given at least 48 hours apart.
¶ Weight-based doses are rounded to nearest 10 mg increment.
Δ Older formulation having lower oral bioavailability and longer time to onset than newer Oxsoralen-Ultra.
◊ Micronized preparations appear to provide greater cutaneous absorption than unmicronized.

Reference:

McNeely W. 5-Methoxypsoralen: A review of its effects in psoriasis and vitiligo. Drugs 1998; 56:4.

Graphic 83021 Version 5.0

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Psoralens used with ultraviolet A light therapy (PUVA) for psoriasis and vitiligo