Pseudorenal panel abnormalities described with paraproteinemia

Chemical	Paraprotein type described	Effect	Mechanism
Sodium	IgG, IgM, IgA	Hyponatremia	Water exclusion effect*
Chloride	IgG	Hypochloridemia	Water exclusion effect
CO₂	IgG, IgM	Hypobicarbonatemia	Interaction between paraprotein and assay reagent
Blood urea nitrogen	IgM	Low urea levels	Paraprotein coats electrodes and interferes with ionic conductance
Creatinine	IgG	Low creatinine levels	Precipitation^¶
Creatinine	IgM	High creatinine levels	Interaction between paraprotein and assay reagent
Calcium	IgA, IgM	Hypercalcemia	Precipitation
Phosphate	IgG, IgM, IgA	Hyperphosphatemia	Precipitation in acid pH
Phosphate	IgG	Hypophosphatemia	Precipitation
Albumin	IgM	Hypoalbuminemia	Slowing of reaction

* Increased colloid phase decreases the aqueous phase per volume of sample resulting in plasma having lower levels of electrolytes per volume of sample.
¶ Immunoglobulins can precipitate or flocculate because of chemical interaction with the test reagents or to their inherent chemical structure.

Graphic 83087 Version 2.0

خرید پکیج

Pseudorenal panel abnormalities described with paraproteinemia