Elevated intraocular pressure: Ophthalmic: One drop in the affected eye(s) once daily in the evening; do not exceed the once daily dosage because it has been shown that more frequent administration may decrease the IOP-lowering effect.
There are no dosage adjustments provided in the manufacturer’s labeling.
There are no dosage adjustments provided in the manufacturer’s labeling.
Refer to adult dosing.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
>10%: Ophthalmic: Conjunctival hyperemia (4% to 20%)
1% to 10%:
Central nervous system: Headache (6%)
Genitourinary: Urinary tract infection (2%)
Infection: Common cold (4%)
Ophthalmic: Eye irritation (≤7%), stinging of eyes (≤7%), conjunctivitis (5%), cataract (3%), eye pain (3%), xerophthalmia (3%), blurred vision (2%), hyperpigmentation of eyelashes (2%), increased eyelash length (2%)
Respiratory: Cough (3%)
<1%, postmarketing, and/or case reports: Dyspnea, exacerbation of asthma, iris hyperpigmentation, iritis, uveitis
There are no contraindications listed in the manufacturer’s prescribing information.
Concerns related to adverse effects:
• Ocular effects: May change/increase brown pigmentation of the iris, eyelid, and eyelashes; length, color, thickness, shape, and/or number of eyelashes may also be increased. Pigmentation of the iris is likely to be permanent although iris color change may not be noticeable for months to years; pigmentation of the eyelid and eyelash changes may be reversible following discontinuation of therapy. Long-term consequences and potential injury to eye are not known.
Disease-related concerns:
• Ocular disease: Use with caution in patients with intraocular inflammation, aphakic patients, pseudophakic patients with a torn posterior lens capsule, or patients with risk factors for macular edema.
Special populations:
• Pediatric: Use in pediatric patients is not recommended due to possible safety issues of increased pigmentation following long-term use.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic [preservative free]:
Zioptan: 0.0015% (10 ea) [contains disodium edta, polysorbate 80]
Generic: 0.0015% (5 ea, 10 ea)
Yes
Solution (Tafluprost (PF) Ophthalmic)
0.0015% (per each): $8.10 - $8.74
Solution (Zioptan Ophthalmic)
0.0015% (per each): $9.20
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For ophthalmic use only. Wash hands before use. Avoid touching the tip of the single-use container to eye or other surfaces. Each single-use container has adequate solution to treat both eyes (if applicable); discard immediately after use. If more than one topical ophthalmic drug is being used, administer the drugs at least 5 minutes apart.
Elevated intraocular pressure: Reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.
Latanoprost: The concomitant use of Prostaglandins (Ophthalmic) and Latanoprost may result in increased intraocular pressure. Risk X: Avoid combination
Nonsteroidal Anti-Inflammatory Agents: May diminish the therapeutic effect of Prostaglandins (Ophthalmic). Nonsteroidal Anti-Inflammatory Agents may also enhance the therapeutic effects of Prostaglandins (Ophthalmic). Risk C: Monitor therapy
Nonsteroidal Anti-Inflammatory Agents (Ophthalmic): May diminish the therapeutic effect of Prostaglandins (Ophthalmic). Nonsteroidal Anti-Inflammatory Agents (Ophthalmic) may enhance the therapeutic effect of Prostaglandins (Ophthalmic). Risk C: Monitor therapy
Ophthalmic prostaglandins, such as tafluprost, have a theoretical risk of miscarriage. To decrease this risk, agents other than tafluprost may be preferred for the treatment of glaucoma in patients planning to become pregnant (Strelow 2020). The manufacturer recommends patients of childbearing potential use effective contraception during treatment with tafluprost
Ophthalmic prostaglandins, such as tafluprost, are generally avoided during pregnancy due to a theoretical risk of miscarriage and premature labor. Agents other than tafluprost may be preferred for the treatment of glaucoma during pregnancy, especially during the first trimester. In general, if ophthalmic agents are needed in pregnancy, the minimum effective dose should be used in combination with punctal occlusion to decrease exposure to the fetus (Belkin 2020; Prum 2016; Strelow 2020).
It is not known if tafluprost is present in breast milk.
The manufacturer recommends that caution be exercised when administering tafluprost to breastfeeding patients. Due to their short half-lives, ophthalmic prostaglandins, such as tafluprost, are considered compatible with breastfeeding; administering after breastfeeding may help decrease potential exposure to the infant via breast milk (Belkin 2020; Prum 2016; Strelow 2020).
Intraocular pressure; regularly examine patients who develop increased iris pigmentation
Tafluprost acid is a fluorinated prostaglandin F2-alpha analog believed to reduce intraocular pressure by increasing outflow of aqueous humor via the uveoscleral pathway; exact mechanism by which it reduces IOP is unknown.
Onset of action: Reduction of intraocular pressure (IOP): 2 to 4 hours
Peak effect: Maximum reduction of IOP: ~12 hours
Absorption: Through the cornea
Metabolism: Ester prodrug (tafluprost) is hydrolyzed to the biologically active acid metabolite (tafluprost acid); tafluprost acid metabolized further via fatty acid beta oxidation and phase II conjugation
Time to peak, plasma: ~10 minutes
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