Mechanisms for urate secretion by the proximal tubule

Urate enters the cell at the basolateral membrane via exchange with alpha-ketoglutarate, mediated by OAT1 and OAT3. At the apical membrane, urate is secreted via MRP4, ABCG2, NPT1, and/or NPT4.

Courtesy of David B Mount, MD, 2012.
Updated with information from:

Johnson RJ, Bakris GL, Borghi C, et al. Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation. Am J Kidney Dis 2018; 71:851.
Mandal AK, Mount DB. The molecular physiology of uric acid homeostasis. Annu Rev Physiol 2015; 77:323.

Graphic 83925 Version 5.0

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