Types of drug reactions associated with eosinophilia

Manifestations	Commonly associated drugs
Asymptomatic	Penicillins, cephalosporins
Soft tissue swelling	GM-CSF, IL-2
Pulmonary infiltrates	NSAIDs
Pneumonitis	Daptomycin
Interstitial nephritis	Semisynthetic penicillins, cephalosporins, NSAIDs
Hepatitis	Semisynthetic penicillins, tetracyclines
Hypersensitivity vasculitis	Allopurinol, phenytoin
Gastroenterocolitis	NSAIDs
Asthma, nasal polyps	Aspirin
Eosinophilia-myalgia syndrome	L-tryptophan contaminant
DRESS	Vancomycin, carbamazepine, allopurinol, lamotrigine, phenobarbital, sulfasalazine, nevirapine, phenytoin, hydrochlorothiazide, cyclosporine

DRESS: drug reaction with eosinophilia and systemic symptoms; GM-CSF: granulocyte-macrophage colony-stimulating factor; IL 2: interleukin 2; NSAIDs: nonsteroidal antiinflammatory drugs.

Original figure modified for this publication. Mejia R, Nutman TB. Evaluation and differential diagnosis of marked, persistent eosinophilia. Semin Hematol 2012; 49:149. Table used with the permission of Elsevier Inc. All rights reserved.

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Types of drug reactions associated with eosinophilia