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خرید پکیج

تعداد آیتم قابل مشاهده باقیمانده : 3 مورد

Contribution to heritability of ankylosing spondylitis of confirmed susceptibility genes

Contribution to heritability of ankylosing spondylitis of confirmed susceptibility genes

Gene name or chromosomal region	Most highly associated SNP	Odds ratio	Overall contribution to AS heritability (percent)
HLA-B27	rs4349859	90.4	23.3
IL23R	rs11209026	1.90	0.31
LTBR-TNFRSF1A	rs11616188	1.38	0.075
2p15	rs10865331	1.36	0.54
ERAP1	rs30187	1.35	0.34
KIF21B	rs2297909	1.25	0.25
21q22	rs378108	1.25	0.035
TBKBP1	rs8070463	1.24	0.054
ANTXR2	rs4389526	1.21	0.054
PTGER4	rs10440635	1.20	0.052
RUNX3	rs11249215	1.19	0.12
IL12B	rs6556416	1.18	0.11
CARD9	rs10781500	1.18	0.034
IL1R2	rs2310173	1.18	0.12
Total:			25.39

NOTE: The estimated heritability contribution of IL23R was increased to 0.35 in a 2013 publication^[1].

SNP: single nucleotide polymorphism.

Reference:

International Genetics of Ankylosing Spondylitis Consortium (IGAS), Cortes A, Hadler J, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013; 45:730.

Reprinted by permission from: Macmillan Publishers Ltd: Nature Reviews Rheumatology. Reveille JD. Genetics of spondyloarthritis - beyond the MHC. Nat Rev Rheumatol 2012; 8:296. Copyright © 2012.

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