Categorization of certain medications by their effects on body weight^[1]

Produce weight loss

Antiseizure medications: topiramate, zonisamide, lamotrigine

Antidepressants: bupropion, venlafaxine, desvenlafaxine

Antipsychotics: ziprasidone

Attention deficit hyperactivity disorder medications: eg, methylphenidate, amphetamine, dextroamphetamine^[2,3]

Are weight neutral

Antipsychotics: haloperidol, aripiprazole

Produce weight gain

Antidepressants: monoamine oxidase inhibitors, tricyclic antidepressants (nortriptyline, amitriptyline, doxepin), paroxetine, citalopram, escitalopram, imipramine, mirtazapine

Antipsychotics: thioridazine, olanzapine, risperidone, clozapine, quetiapine

Diabetes medications: eg, insulin, sulfonylureas, thiazolidinediones, meglitinides

Glucocorticoids: eg, prednisone

Hormonal agents: especially progestins, eg, medroxyprogesterone

Antiseizure medications: eg, divalproex

Neurologic and mood-stabilizing agents: eg, lithium, carbamazepine, gabapentin, valproate

Antihistamines: cyproheptadine

Alpha blockers: especially terazosin

Beta blockers: especially propranolol

Reference:

Tsai AG, Wadden TA. In the Clinic: Obesity. Ann Intern Med 2013; 159:ITC3-1.
Catalá-López F, Hutton B, Núñez-Beltrán A, et al. The pharmacological and non-pharmacological treatment of attention deficit hyperactivity disorder in children and adolescents: A systematic review with network meta-analyses of randomised trials. PLoS One 2017; 12:e0180355.
Goldfield GS, Lorello C, Doucet E. Methylphenidate reduces energy intake and dietary fat intake in adults: a mechanism of reduced reinforcing value of food? Am J Clin Nutr 2007; 86:308.

Adapted from: Bray GA, Ryan DH. Medical therapy for the patient with obesity. Circulation 2012; 125:1695.

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Categorization of certain medications by their effects on body weight[1]

Categorization of certain medications by their effects on body weight^[1]