Version May 2024
| Architecture |
| Diameter <5 to 6 mm* |
| Symmetric outline* |
| Sharp lateral circumscription* |
| Regular pattern of epidermal hyperplasia |
| Maturation with depth in dermis |
| Zonation across the horizontal axis |
| Wedge-shaped configuration within dermis |
| Orderly nondisruptive infiltration of collagen by melanocytes |
| Cytology |
| Spindle or epithelioid cell type* |
| Uniform population of cells* |
| Low nuclear-to-cytoplasmic ratio |
| Opaque or ground glass cytoplasm |
| Nuclei with open, delicate chromatin pattern |
| Uniform nucleoli |
| Rare pleomorphism |
| Other helpful diagnostic features |
| Mitotic rate <2/mm2* |
| Absent or rare mitoses in deep dermis* |
| Lack of atypical mitoses* |
| Irregular contours of growth at deep margin* |
| Kamino bodies* |
| Mononuclear or multinucleate giant cells |
| Minimal central pagetoid upward scatter |
| Junctional clefts |
| Loss of cohesion between cells (retraction spaces) |
| Perivascular or diffuse inflammation |
| Superficial distribution of pigmentation |
| Telangiectasia and edema |
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