Hepatosplenic T cell lymphoma tumor cells express CD2 (panel A) and surface CD3 (panel B). In most cases, CD5 (panel C) and CD 8 (panel D) are not expressed. The cytotoxic granule protein TIA-1 (panel E) is expressed, but perforin (panel F) and granzyme B (panel G) are absent, features consistent with a non-activated cytotoxic T cell phenotype. Mitotic activity (panel H) is generally low.
Kindly provided by German Pihan, MD, Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA.
