Clinical features of Sweet syndrome

Characteristic	Clinical form
Characteristic	Classical*	Hematologic malignancy*	Solid tumor*	Drug-induced^¶
Epidemiology
Women	80	50	59	71
Prior upper respiratory tract infection	75-90	16	20	21
Recurrence^Δ	30	69	41	67
Clinical symptoms
Fever^◊	80-90	88	79	100
Musculoskeletal involvement	12-56	26	34	21
Ocular involvement	17-72	7	15	21
Lesion location
Upper extremities	80	89	97	71
Head and neck	50	63	52	43
Trunk and back	30	42	33	50
Lower extremities	Infrequent	49	48	36
Oral mucous membranes	2	12	3	7
Laboratory findings
Neutrophilia^§	80	47	60	38
Elevated erythrocyte sedimentation rate^¥	90	100	95	100
Anemia^‡	Infrequent	82	83	100
Abnormal platelet count^†	Infrequent	68	50	50
Abnormal renal function**	11-50	15	7	0

* Percentages for classical, hematologic malignancy, and solid tumor associated Sweet syndrome adapted with permission from Cohen PR, Kurzrock R: Sweet's syndrome and cancer. Clin Dermatol 1993; 11:149-157. Copyright 1993, Reprinted with permission from Elsevier Ltd, Oxford, United Kingdom.
¶ Percentages for drug-induced Sweet syndrome adapted with permission from Walker DC, Cohen PR: Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug induced Sweet's syndrome. J Am Acad Dermatol 1996; 34:918–923. Copyright 1996, Reprinted with permission from the American Academy of Dermatology, Inc., Elsevier Ltd, Oxford, United Kingdom.
Δ Recurrence following oral rechallenge testing in the patients with drug-induced Sweet syndrome.
◊ Temperature greater than 38°C.
§ Neutrophil count greater than 6,000 cells/ul.
¥ Erythrocyte sedimentation rate greater than 20 mm/hr.
‡ Hemoglobin less than 13 g/dl in men and less than 12 g/dl in women.
† Platelet count less than 150,000/ul or greater than 500,000/ul.
** This includes hematuria, proteinuria, and renal insufficiency.

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Clinical features of Sweet syndrome