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Strategies to prevent Cryptosporidium infection in patients with CD40L deficiency

Strategies to prevent Cryptosporidium infection in patients with CD40L deficiency
Drinking water should be boiled and/or filtered
Avoid swimming in lakes, ponds, and nonchlorinated pools
Avoid contact with farm animals
Prophylactic use of azithromycin may reduce the risk of infection and is usually indicated, but its long-term efficacy in preventing Cryptosporidium infection is not known
In addition, the following surveillance studies should be done every 6 to 12 months:
  • Test the stools by polymerase chain reaction (PCR) for the presence of Cryptosporidium
  • Perform liver function tests (aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyl transpeptidase [GGT], alkaline phosphatase, bilirubin)
  • Liver ultrasound
CD40L: CD40 ligand.
Graphic 86095 Version 4.0

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