Mean effect sizes and symptom ratings by premenstrual dysphoric disorder symptom or functioning measure and perimenstrual interval in 864 participants in the community sample

Symptom*	Symptom rating^¶		Effect size^Δ
Symptom*	Day of peak	Mean rating at peak	(–6, –1)	(–5, 1)	(–4, 2)	(–3, 3)
Physical symptoms, eg, bloating	1	2.87	0.33	0.49	0.58	0.62
Food cravings	1	1.84	0.24	0.27	0.29	0.31
Low sex drive	1	1.9	0.21	0.27	0.29	0.29
Mood swings	1	1.83	0.2	0.26	0.28	0.29
Change in appetite	1	1.85	0.15	0.2	0.23	0.24
Suddenly sad or tearful	2	1.7	0.13	0.18	0.22	0.23
Suddenly irritable	1	1.93	0.15	0.2	0.21	0.22
Sensitive to rejection	1	1.74	0.15	0.18	0.2	0.2
Irritability that stayed with me	1	1.72	0.16	0.2	0.19	0.18
Easily upset	1	1.86	0.13	0.17	0.18	0.18
Symptoms interfered with getting things done at work	1	1.66	0.14	0.16	0.18	0.2
Felt "on edge"	1	1.73	0.12	0.16	0.17	0.17
Depressed mood	1	1.72	0.1	0.14	0.16	0.18
Symptoms interfered with relationships at home	1	1.6	0.09	0.15	0.16	0.17
Wanted to be alone	1	1.86	0.12	0.15	0.16	0.16
Felt distractible	1	1.62	0.1	0.15	0.15	0.17
Symptoms interfered with relationships at work	1	1.63	0.14	0.15	0.15	0.16
Felt "out of control"	1	1.41	0.11	0.14	0.15	0.16
Increased interpersonal conflict	3	1.61	0.13	0.15	0.15	0.13
Feelings of tension	1	2.12	0.1	0.14	0.15	0.15
No energy	1	2.25	0.05	0.1	0.14	0.18
Easily fatigued	1	2.18	0.04	0.1	0.14	0.17
Agitated	1	1.92	0.11	0.13	0.14	0.14
Negative thoughts about myself	1	1.61	0.1	0.15	0.14	0.14
Time missed from work	1	NA	0.06	0.1	0.14	0.13
Overeating	1	1.71	0.15	0.15	0.14	0.14
Symptoms interfered with social activities	1	1.62	0.07	0.11	0.14	0.15
Felt restless	1	1.74	0.09	0.12	0.14	0.14
Felt suddenly angry	1	1.68	0.09	0.12	0.13	0.11
Arguments with people	1	1.36	0.11	0.13	0.13	0.12
Felt "keyed up"	1	1.59	0.09	0.12	0.13	0.11
Decreased interest in usual activities	1	1.63	0.07	0.11	0.12	0.14
Symptoms interfered with getting things done at home	1	1.75	0.06	0.11	0.12	0.14
Trouble sleeping	1	1.87	0.08	0.11	0.11	0.13
Less productive at home	1	1.89	0.05	0.09	0.11	0.13
Difficulty concentrating	1	1.81	0.05	0.08	0.11	0.13
Less productive at work	1	1.12	0.05	0.08	0.11	0.14
Symptoms interfered with getting things done at school	1	1.52	–0.04	0.06	0.1	0.14
Avoided social activities	1	1.53	0.04	0.07	0.09	0.1
Anger that stayed with me	1	1.51	0.09	0.09	0.09	0.08
Felt hopeless	1	1.48	0.05	0.07	0.08	0.09
Slept too much	1	1.49	0.05	0.07	0.08	0.08
Felt lonely	1	1.62	0.04	0.07	0.07	0.08
Felt anxious	1	1.97	0.02	0.05	0.07	0.08
Felt guilty	1	1.48	0.03	0.04	0.05	0.04
Felt overwhelmed	1	1.91	0.01	0.04	0.04	0.05
Time missed from class	1	NA	0.11	–1.01	0.03	0.06
Symptoms interfered with relationships at school	1	1.64	0.09	–0.02	–0.05	0.01

NA: not applicable.
* Symptoms are presented in descending order of severity and change during the last four days before and the first two days of the menstrual period.
¶ Ratings are on a six-point scale: 1 indicates not at all; 2, minimal; 3, mild; 4, moderate; 5, severe; and 6, extreme.
Δ Effect size measures the increase in symptom endorsement during the perimenstrual interval compared with a nonmenstrual interval adjusted for the standard deviation of symptom endorsement during the entire cycle. The interval (–6, –1) indicates six days before through one day before menses; (–5, 1), five days before through the first day of menses; (–4, 2), four days before through the first two days of menses; and –3, 3), three days before through the first three days of menses.

Reproduced with permission from: Hartlage SA, Freels S, Gotman N, Yonkers K. Criteria for Premenstrual Dysphoric Disorder. Arch Gen Psychiatry 2012; 69:300. Copyright © 2012 American Medical Association. All rights reserved.

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Mean effect sizes and symptom ratings by premenstrual dysphoric disorder symptom or functioning measure and perimenstrual interval in 864 participants in the community sample