Diagnostic criteria for diffuse panbronchiolitis*

Noninvasive

Persistent cough, sputum, and exertional dyspnea

History or current symptoms of chronic sinusitis

Bilateral, diffuse, small nodular shadows on a plain chest radiograph or centrilobular micronodules on chest CT images

Coarse crackles

FEV₁/FVC less than 70 percent and PaO₂ less than 80 mmHg (10.64 kPa)

Titer of cold agglutinins of 64 or greater

Lung biopsy

Lung biopsy showing inflammation centered on the respiratory bronchioles with a transmural infiltrate composed of lymphocytes, plasma cells, and distinctive lipid-laden "foamy" macrophages, also known as foam cells*

FEV₁/FVC: forced expiratory volume in one second/forced vital capacity; PaO₂: arterial tension for oxygen.
* In regions where diffuse panbronchiolitis is endemic (eg, East Asia), a lung biopsy is not needed if the patient fulfills the first three criteria and at least two of the second three.

Data from: Kudoh S, Keicho N. Diffuse panbronchiolitis. Clin Chest Med 2012; 33:297.

Graphic 86536 Version 2.0

خرید پکیج

Diagnostic criteria for diffuse panbronchiolitis*