Version July 2025
Acne vulgaris: Topical: Apply thin film 1 to 3 times/day.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Adolescents ≥12 years: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
See individual agents.
Hypersensitivity to benzoyl peroxide, hydrocortisone, or any component of the formulation; viral diseases of the skin (eg, varicella)
Concerns related to adverse effects:
• Bleaching effects: May bleach hair or colored fabric.
Concurrent drug therapy issues:
• Sulfone products: Concomitant use of benzoyl peroxide with sulfone products (eg, dapsone, sulfacetamide) may cause temporary discoloration (yellow/orange) of facial hair and skin. Application of products at separate times during the day or washing off benzoyl peroxide prior to application of other products may avoid skin discoloration (Dubina 2009).
• Topical acne products: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with mucous membranes and eyes. Inform patients to use skin protection and minimize prolonged exposure to sun or tanning beds.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Lotion, External:
Vanoxide-HC: Benzoyl peroxide 5% and hydrocortisone 0.5% (25 g)
Generic: Benzoyl peroxide 5% and hydrocortisone 0.5% (113 g); Benzoyl peroxide 7.5% and hydrocortisone 1% (113 g)
Yes
Lotion (Benzoyl Perox-Hydrocortisone External)
5-0.5% (per gram): $19.91
Lotion (Vanoxide-HC External)
5-0.5% (per gram): $14.40
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: Shake well prior to use. For external use only; avoid applying to inside nose, mouth, eyes, vagina, mucous membranes, and on areas of broken skin. Use caution on neck and other sensitive areas. Skin should be clean and dry before applying. Gently massage lotion to blend into skin. May bleach or stain certain fabrics; avoid contact with clothing or furniture.
Topical: For external use only; avoid applying to inside nose, mouth, eyes, vagina, mucous membranes, and on areas of broken skin. Shake well prior to use. Wash hand before and after use. Skin should be clean and dry before applying. Gently massage lotion to blend into skin. Use caution on neck and other sensitive areas. Avoid contact with clothing or furniture; may bleach or stain certain fabrics.
Acne vulgaris: Treatment of acne vulgaris and oily skin
KIDs List: Medium, high, and very high potency topical corticosteroids, when used in neonates and infants <1 year of age for diaper dermatitis, are identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list; use should be avoided due to risk of adrenal suppression; systemic absorption is higher in pediatric patients than adults (strong recommendation; low quality of evidence) (PPA [Meyers 2020]).
Refer to individual components.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Aminolevulinic Acid (Systemic): Photosensitizing Agents may increase photosensitizing effects of Aminolevulinic Acid (Systemic). Risk X: Avoid
Aminolevulinic Acid (Topical): Photosensitizing Agents may increase photosensitizing effects of Aminolevulinic Acid (Topical). Risk C: Monitor
Calcipotriene: Hydrocortisone (Topical) may decrease therapeutic effects of Calcipotriene. Management: Monitor for reduced calcipotriene efficacy if combined with hydrocortisone valerate. Consider separating the administration of these agents by 10 to 12 hours to minimize the risk of this potential interaction. Risk C: Monitor
Dapsone (Topical): Benzoyl Peroxide may increase adverse/toxic effects of Dapsone (Topical). Specifically, the use of these agents in combination may cause skin and facial hair to temporarily turn a tan or yellow/orange color. Risk C: Monitor
Methoxsalen (Systemic): Photosensitizing Agents may increase photosensitizing effects of Methoxsalen (Systemic). Risk C: Monitor
Porfimer: Photosensitizing Agents may increase photosensitizing effects of Porfimer. Risk X: Avoid
Verteporfin: Photosensitizing Agents may increase photosensitizing effects of Verteporfin. Risk C: Monitor
Animal reproduction studies have not been conducted with this combination. See individual agents.
See individual agents.
See individual agents.
