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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
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Approach to treatment of a patient with lymphatic filariasis, onchocerciasis, and/or loiasis

Approach to treatment of a patient with lymphatic filariasis, onchocerciasis, and/or loiasis
Lymphatic filariasis Onchocerciasis Loiasis Treatment of choice Alternative treatments Comments
+ - - DEC (6 mg/kg for 12 days)*
  1. IVM (200 mcg/kg) + ALB (400 mg)
  2. IVM (200 mcg/kg) + DEC (6 mg/kg)
  3. ALB (200 mg twice daily for 21 days)
  4. DOXY (200 mg daily for six weeks)
 
- + - IVM (150 mcg/kg every 6 to 12 months) IVM (150 mcg/kg) + DOXY (200 mg daily for six weeks) DEC can cause severe post-treatment reactions and exacerbate ocular disease
- - +

Low microfilariae: DEC (8 mg/kg/day for 21 days)

High microfilariae: Apheresis or ALB (200 mg twice daily for 21 days) to lower microfilariae count prior to DEC		 ALB (200 mg twice daily for 21 days) DEC and IVM can provoke serious side effects in patients with high microfilariae counts
+ + - IVM (150 mcg/kg) followed by DEC (6 mg/kg for 12 days)
  1. IVM (200 mcg/kg) + ALB (400 mg)
  2. IVM + ALB (200 mg twice daily for 21 days)
  3. IVM + DOXY (200 mg daily for six weeks)
Pretreatment with IVM to clear Onchocerca microfilariae is necessary prior to administration of DEC for LF
+ - + Same as Loa alone Same as Loa alone Same as Loa alone
- + +

Low microfilariae: IVM (150 mcg/kg) followed by DEC (8 mg/kg for 21 days)

High microfilariae: Apheresis to lower microfilariae prior to IVM followed by DEC (as for low microfilariae)		 IVM (150 mcg/kg) + ALB (200 mg twice daily for 21 days) Due to the slow effect of ALB on Loa microfilariae, ALB should only be used as an alternative to apheresis to lower Loa microfilariae if there is no evidence of onchocercal eye involvement
+ + + Same as Onchocerca + Loa Same as Onchocerca + Loa Same as Onchocerca + Loa
DEC: diethylcarbamazine; IVM: ivermectin; ALB: albendazole; DOXY: doxycycline.
* A longer course (14 to 21 days) is recommended for tropical pulmonary eosinophilia.
¶ This regimen has only been demonstrated to be effective in DEC-refractory disease.
Graphic 86736 Version 2.0

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