Allergic conjunctivitis: Ophthalmic: Instill 1 drop into affected eye(s) twice daily.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
(For additional information see "Azelastine (ophthalmic): Pediatric drug information")
Seasonal allergic conjunctivitis: Children ≥3 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) twice daily
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely needed due to low systemic absorption.
The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.
>10%:
Central nervous system: Headache (15%)
Ocular: Transient burning/stinging (30%)
1% to 10%:
Central nervous system: Fatigue
Dermatologic: Pruritus
Gastrointestinal: Bitter taste (10%)
Ocular: Conjunctivitis, eye pain, blurred vision (temporary)
Respiratory: Asthma, dyspnea, pharyngitis, rhinitis
Miscellaneous: Flu-like syndrome
Hypersensitivity to azelastine or any component of the formulation
Dosage form specific issues:
• Solution contains benzalkonium chloride; remove lens prior to administration and wait at least 10 minutes before reinserting. Do not use contact lenses if eyes are red.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Solution, Ophthalmic, as hydrochloride:
Generic: 0.05% (6 mL)
Yes
Solution (Azelastine HCl Ophthalmic)
0.05% (per mL): $1.80 - $17.35
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
For topical ophthalmic use only. Wash hands prior to use. Do not touch tip of container to any surface, the eyelids, or surrounding areas. After instilling drops, wait at least 10 minutes before inserting contact lenses. Do not insert contacts if eyes are red.
For topical ophthalmic use only. Do not allow the bottle tip to touch any surface, the eyelids, or surrounding areas. Apply gentle pressure to lacrimal sac during and immediately following instillation (1 minute) or instruct patient to gently close eyelid after administration, to decrease systemic absorption of ophthalmic drops (Ref). Patients should not wear contact lenses if their eye is red. For contact lens users whose eyes are not red, wait at least 10 minutes after instilling medication to insert contact lenses.
Allergic conjunctivitis: Treatment of itching of the eye associated with allergic conjunctivitis
Optivar may be confused with Optiray, Optive
Optivar [US] may be confused with Opthavir brand name for acyclovir [Mexico]
None known.
There are no known significant interactions.
Animal reproduction studies have shown toxic effects to the fetus at maternally toxic doses.
It is not known if azelastine (ophthalmic) is excreted in breast milk. The manufacturer recommends that caution be exercised when administering azelastine (ophthalmic) to nursing women.
Competes with histamine for H1-receptor sites on effector cells and inhibits the release of histamine and other mediators involved in the allergic response
Onset of action: Peak effect: 3 minutes
Duration: 8 hours
Absorption: Plasma concentrations following ocular administration are low for azelastine (0.02-0.25 ng/mL) and n-desmethylazelastine (0.25-0.87 ng/mL)
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