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Bacitracin, neomycin, polymyxin B, and pramoxine: Drug information

Bacitracin, neomycin, polymyxin B, and pramoxine: Drug information
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Brand Names: US
  • FT Triple Antibiotic + Pain [OTC];
  • Neosporin + Pain Relief Max St [OTC];
  • Triple Antibiotic Pain Relief [OTC];
  • Triple Antibiotic Plus Max St [OTC];
  • Triple Antibiotic Plus [OTC]
Pharmacologic Category
  • Antibiotic, Topical
Dosing: Adult
Topical infection/pain prevention

Topical infection/pain prevention: Topical: Apply a small amount to the affected area 1 to 3 times daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Bacitracin, neomycin, polymyxin B, and pramoxine: Pediatric drug information")

Prevention of infection and relief of pain and discomfort

Prevention of infection and relief of pain and discomfort: Children ≥2 years and Adolescents: Topical: Ointment: Apply a small amount (should not exceed surface area of fingertip) to affected area 1 to 3 times daily; may cover with sterile bandage if necessary

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Dosing: Liver Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

See individual agents.

Contraindications

OTC labeling: When used for self-medication, do not use if hypersensitive to bacitracin, neomycin, polymyxin B, pramoxine, or any component of the formulation.

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylaxis: Use with caution in patients who have been previously exposed to bacitracin; anaphylactic reactions have occurred on repeat exposure (Elsner 1990; Farley 1995).

Other warnings/precautions:

• Self-medication (OTC use): When used for self-medication (OTC), do not use in the eyes, over large areas of the body, or for >1 week unless directed by health care provider. Discontinue use and notify health care provider prior to use for deep puncture wounds, bites, or serious burns, if condition persists or worsens, or if rash or other allergic reaction occurs.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, External:

FT Triple Antibiotic + Pain: Bacitracin 500 units, neomycin 3.5 mg, polymyxin b 10,000 units, and pramoxine hydrochloride 10 mg per g (28.4 g)

Neosporin + Pain Relief Max St: Bacitracin 500 units, neomycin 3.5 mg, polymyxin b 10,000 units, and pramoxine hydrochloride 10 mg per g (14.2 g, 28.3 g, 56.7 g)

Triple Antibiotic Pain Relief: Bacitracin 500 units, neomycin 3.5 mg, polymyxin b 10,000 units, and pramoxine hydrochloride 10 mg per g (28 g)

Triple Antibiotic Plus: Bacitracin 500 units, neomycin 3.5 mg, polymyxin b 10,000 units, and pramoxine hydrochloride 10 mg per g (15 g, 28.4 g)

Triple Antibiotic Plus Max St: Bacitracin 500 units, neomycin 3.5 mg, polymyxin b 10,000 units, and pramoxine hydrochloride 10 mg per g (30 g)

Generic Equivalent Available: US

Yes

Pricing: US

Ointment (Neosporin + Pain Relief Max St External)

1% (per gram): $0.36

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: For topical use only; do not use in the eyes or over large areas of the body. Clean affected area prior to application. Apply a small amount of product (an amount equal to the surface area of the tip of a finger); may cover with sterile bandage.

Administration: Pediatric

Topical: For application to the skin; avoid eyes. Clean the affected area prior to use. Apply to affected area; may cover with a sterile bandage. Wash hands after application.

Use: Labeled Indications

Topical infection/pain prevention: Prevention of infection and relief of pain in minor cuts, scrapes, or burns.

Pregnancy Considerations

Refer to individual monographs.

Breastfeeding Considerations

Refer to individual monographs.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (DO) Dominican Republic: Curaderm;
  • (EG) Egypt: Pramover | Utopia neo;
  • (KR) Korea, Republic of: Antiforce | Any cure | Caremixin plus | Elcoporin | Neopraxine | Plmycin | Poolmiksin | Quad care;
  • (PR) Puerto Rico: Bactine Pain Relieving Protective Antibiotic | Neosporin + pain relief | Neosporin+ pain ich scar | Triple antibiotic plus pain relief
  1. Elsner P, Pevny I, Burg G. Anaphylaxis induced by topically applied bacitracin. Am J Contact Dermat. 1990;1(3):162-164.
  2. Farley M, Pak H, Carregal V, Engler R, James W. Anaphylaxis to topically applied bacitracin. Am J Contact Dermat. 1995;6(1):28-31.
  3. Neosporin Plus Pain Relief (bacitracin zinc, neomycin sulfate, polymyxin b sulfate, pramoxine hydrochloride) [prescribing information]. Skillman, NJ: Johnson & Johnson Consumer Inc; received June 2020.
Topic 8681 Version 102.0