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Bacitracin, neomycin, polymyxin B, and pramoxine: Drug information

Bacitracin, neomycin, polymyxin B, and pramoxine: Drug information
(For additional information see "Bacitracin, neomycin, polymyxin B, and pramoxine: Patient drug information" and see "Bacitracin, neomycin, polymyxin B, and pramoxine: Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Neosporin® + Pain Relief Ointment [OTC];
  • Tri Biozene [OTC]
Pharmacologic Category
  • Antibiotic, Topical
Dosing: Adult
Topical infection/pain prevention

Topical infection/pain prevention: Topical: Apply to affected area 1 to 3 times/day; may cover with sterile bandage if needed.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Bacitracin, neomycin, polymyxin B, and pramoxine: Pediatric drug information")

Prevention of infection and relief of pain and discomfort

Prevention of infection and relief of pain and discomfort: Children ≥2 years and Adolescents: Topical: Ointment: Apply a small amount (should not exceed surface area of fingertip) to affected area 1 to 3 times daily; may cover with sterile bandage if necessary

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling; however, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

See individual agents.

Contraindications

Hypersensitivity to bacitracin, neomycin, polymyxin B, pramoxine, or any component of the formulation

Warnings/Precautions

Other warnings/precautions:

• Self-medication (OTC use): Use longer than 1 week is not recommended unless directed by prescriber. Do not use in eyes or over large areas of the body. Seek advice from health care provider prior to use for deep puncture wounds, animal bites, or serious burns, or if condition lasts longer than 1 week. Stop use and consult healthcare provider if rash or allergic reaction occurs.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Ointment, topical: Bacitracin 500 units, neomycin 3.5 mg, polymyxin B 10,000 units, and pramoxine hydrochloride 10 mg (15 g, 30 g)

Neosporin® + Pain Relief Ointment: Bacitracin 500 units, neomycin 3.5 mg, polymyxin B 10,000 units, and pramoxine hydrochloride 10 mg per g (15 g, 30 g)

Tri Biozene: Bacitracin 500 units, neomycin 3.5 mg, polymyxin B 10,000 units, and pramoxine hydrochloride 10 mg per g (15 g)

Generic Equivalent Available: US

Yes

Pricing: US

Ointment (Neosporin + Pain Relief Max St External)

1% (per gram): $0.31

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Topical: For external use only. Clean affected area prior to application. Apply amount equal to the surface area of the tip of the finger. Do not use topical ointment in the eyes or over large areas of the body; avoid contact of the tube tip with skin.

Administration: Pediatric

Topical: For application to the skin; avoid eyes. Clean the affected area prior to use. Apply to affected area; may cover with a sterile bandage. Wash hands after application.

Use: Labeled Indications

Topical infection/pain prevention: Prevention of infection and relief of pain in minor cuts, scrapes, or burns.

Pregnancy Considerations

Refer to individual monographs.

Breastfeeding Considerations

Refer to individual monographs.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (DO) Dominican Republic: Curaderm;
  • (EG) Egypt: Pramover | Utopia neo;
  • (KR) Korea, Republic of: Antiforce | Any cure | Caremixin plus | Elcoporin | Neopraxine | Plmycin | Poolmiksin | Quad care;
  • (PR) Puerto Rico: Bactine Pain Relieving Protective Antibiotic | Neosporin+ pain ich scar | Triple antibiotic plus pain relief
  1. Neosporin Plus Pain Relief (bacitracin zinc, neomycin sulfate, polymyxin b sulfate, pramoxine hydrochloride) [prescribing information]. Skillman, NJ: Johnson & Johnson Consumer Inc; received June 2020.
Topic 8681 Version 84.0

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