Version July 2025
Dietary supplement: Oral: 1 to 2 tablets daily or as directed by health care provider.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
See individual agents.
Hypersensitivity to folic acid, cyanocobalamin, pyridoxine, or any component of the formulation
See individual agents.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Capsule, Oral:
Biopar delta-Forte: Folic Acid 1 mg, cyanocobalamin 400 mcg, and pyridoxine hydrochloride 50 mg [DSC] [dairy free, egg free, gluten free, no artificial color(s), sugar free, wheat free; contains gelatin (bovine), phosphatidylserine, pork (porcine) protein]
Generic: Folic Acid 1 mg, cyanocobalamin 400 mcg, and pyridoxine hydrochloride 50 mg
Tablet, Oral:
Airavite: Folic acid 2.5 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [lactose free, sugar free]
CenFol: Folic acid 2.3 mg, cyanocobalamin 2 mg, and pyridoxine hydrochloride 24.5 mg
FaBB: Folic acid 2.2 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [DSC]
Folbee: Folic acid 2.5 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [dye free, lactose free, sugar free]
Folbic: Folic acid 2.5 mg, cyanocobalamin 2 mg, and pyridoxine hydrochloride 25 mg [lactose free, sugar free; contains carmine (cochineal extract)]
Folgard RX: Folic acid 2.2 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [scored; contains sodium benzoate]
Folplex 2.2: Folic acid 2.2 mg, cyanocobalamin 0.5 mg, and pyridoxine hydrochloride 25 mg [scored; alcohol free, gluten free, lactose free, sugar free; contains fd&c yellow #6(sunset yellow)alumin lake]
Foltabs 800: Folic acid 0.8 mg, cyanocobalamin 0.115 mg, and pyridoxine hydrochloride 10 mg [scored; contains fd&c blue #1 (brill blue) aluminum lake, fd&c yellow #6(sunset yellow)alumin lake, quinoline (d&c yellow #10) aluminum lake]
NuFol: Folic acid 2.5 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [dye free, lactose free, sugar free]
Virt-Gard: Folic acid 2.2 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [DSC]
WesTab Max: Folic acid 2.5 mg, cyanocobalamin 2 mg, and pyridoxine hydrochloride 25 mg [lactose free, sugar free; contains fd&c red #40 (allura red ac dye), fd&c red #40(allura red ac)aluminum lake]
WesTab Mini: Folic acid 2.2 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [DSC] [contains fd&c red #40 (allura red ac dye), fd&c yellow #6 (sunset yellow)]
WesTab One: Folic acid 2.5 mg, cyanocobalamin 1 mg, and pyridoxine hydrochloride 25 mg [lactose free, sugar free; contains fd&c red #40 (allura red ac dye), fd&c red #40(allura red ac)aluminum lake, fd&c yellow #5 (tartrazine), fd&c yellow #5 (tartrazine)aluminum lake, fd&c yellow #6 (sunset yellow), fd&c yellow #6(sunset yellow)alumin lake]
Generic: Folic acid 2.2 mg, cyanocobalamin 0.5 mg, and pyridoxine hydrochloride 25 mg
Tablet, Oral [preservative free]:
Niva-Fol: Folic acid 2.5 mg, cyanocobalamin 2 mg, and pyridoxine hydrochloride 25 mg [egg free, milk derivatives/products, no artificial color(s), no artificial flavor(s), salt free, shellfish free, sugar free, yeast free; contains carmine (cochineal extract)]
Generic: Folic acid 0.5 mg, cyanocobalamin 0.2 mg, and pyridoxine hydrochloride 5 mg
Yes
Tablets (Airavite Oral)
2.5-25-1 mg (per each): $0.52
Tablets (CenFol Oral)
2.3-24.5-2 mg (per each): $1.07
Tablets (Folbic Oral)
2.5-25-2 mg (per each): $0.91
Tablets (Folgard RX Oral)
2.2-25-1 mg (per each): $0.63
Tablets (Foltabs 800 Oral)
800-10-115 mcg-mg-mcg (per each): $0.50
Tablets (Niva-Fol Oral)
2.5-25-2 mg (per each): $0.91
Tablets (NuFol Oral)
2.5-25-1 mg (per each): $0.44
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Dietary supplement: Nutritional supplement in end-stage renal failure, dialysis, hyperhomocysteinemia, homocystinuria, malabsorption syndromes, dietary deficiencies.
Refer to individual components.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Chloramphenicol (Systemic): May decrease therapeutic effects of Vitamin B12. Risk C: Monitor
Fluorouracil Products: Folic Acid may increase adverse/toxic effects of Fluorouracil Products. Risk C: Monitor
Fosphenytoin-Phenytoin: Folic Acid may decrease serum concentration of Fosphenytoin-Phenytoin. Risk C: Monitor
Fosphenytoin-Phenytoin: Pyridoxine may decrease serum concentration of Fosphenytoin-Phenytoin. Risk C: Monitor
Green Tea: May decrease serum concentration of Folic Acid. Risk C: Monitor
Levodopa-Foslevodopa: Pyridoxine may decrease therapeutic effects of Levodopa-Foslevodopa. Management: The concomitant use of pyridoxine and levodopa (in the absence of a dopa decarboxylase inhibitor (DDI)) should be avoided. Use of a DDI (eg, carbidopa) with levodopa will essentially eliminate the risk of this interaction. Risk D: Consider Therapy Modification
Pafolacianine: Coadministration of Folic Acid and Pafolacianine may alter diagnostic results. Risk X: Avoid
PHENobarbital: Folic Acid may decrease serum concentration of PHENobarbital. Risk C: Monitor
PHENobarbital: Pyridoxine may decrease serum concentration of PHENobarbital. Risk C: Monitor
Primidone: Folic Acid may decrease serum concentration of Primidone. Additionally, folic acid may decrease concentrations of active metabolites of primidone (e.g., phenobarbital). Risk C: Monitor
Primidone: Pyridoxine may decrease active metabolite exposure of Primidone. Specifically, concentrations of phenobarbital may be reduced. Risk C: Monitor
Pyrimethamine: Folic Acid may decrease therapeutic effects of Pyrimethamine. Management: Folic acid doses greater than 2.5 mg per day should be avoided due to the potential for sulfadoxine/pyrimethamine treatment failure. Consider limiting folic acid use to no more than 0.4 mg per day for women of child-bearing age. Risk D: Consider Therapy Modification
Raltitrexed: Folic Acid may decrease therapeutic effects of Raltitrexed. Risk X: Avoid
Sulfadoxine: Folic Acid may decrease therapeutic effects of Sulfadoxine. Management: Folic acid doses greater than 2.5 mg per day should be avoided due to the potential for sulfadoxine/pyrimethamine treatment failure. Consider limiting folic acid use to no more than 0.4 mg per day for women of child-bearing age. Risk D: Consider Therapy Modification
SulfaSALAzine: May decrease serum concentration of Folic Acid. Risk C: Monitor
See individual agents.
See individual agents.
