Microscopic images of secondary breast angiosarcoma

Left panel reveals a low power view of a photomicrograph of a radiation-associated angiosarcoma. Note the cellular proliferation within the dermis, including pockets of cells, single cells percolating between dermal collagen, and columns of cells that appear to raise the epidermis, forming blisters/nodules (corresponding to the gross appearance of these tumors on the chest wall). Right panel reveals a higher power view of the same tumor showing predominantly spindle cells (and rare epithelioid cells) with large, oval to round vesicular nuclei containing one or more prominent nucleoli and basophilic cytoplasm. These malignant cells form vasoformative channels (arrows) containing erythrocytes.