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Management of hypoxemia during one lung ventilation[1]

Management of hypoxemia during one lung ventilation[1]
Gradual desaturation:
Ensure FiO2 = 1.0
Check DLT/BB placement with fiberoptic bronchoscopy
Suction airway as needed
Optimize cardiac output
Recruit ventilated lung
Apply PEEP 5 cm to ventilated lung (except COPD)
Apply CPAP 5 to 10 cm non-ventilated lung (after recruitment)
Intermittently ventilate both lungs
Partial ventilation of operative lung:
i) Selective lobar collapse
ii) O2 insufflation to non-operative lobes
Mechanical restriction of pulmonary blood flow to non-ventilated lung
If hypoxemia is acute and severe (O2 saturation <90 percent), two lung ventilation should be resumed until oxygenation is felt to be clinically adequate. The patient should be assessed after each maneuver; proceed to the next maneuver if hypoxemia persists. When oxygenation is adequate during one lung ventilation, subsequent steps are not necessary.
FiO2: fractional inspired concentration of oxygen; DLT: double-lumen tube; BB: bronchial blocker; PEEP: positive end expiratory pressure; COPD: chronic obstructive pulmonary disease; CPAP: continuous positive airway pressure; O2: oxygen.
Reference:
  1. Lohser J, Slinger P. Lung Injury After One-Lung Ventilation: A Review of the Pathophysiologic Mechanisms Affecting the Ventilated and the Collapsed Lung. Anesth Analg 2015; 121:302.
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