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Topical polyureaurethane: Drug information

Topical polyureaurethane: Drug information
For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Nuvail™
Pharmacologic Category
  • Protectant, Topical
Dosing: Adult
Nail dystrophy

Nail dystrophy: Topical: Apply once daily before bedtime to affected nail(s)

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not defined: Dermatologic: Skin irritation, stinging of the skin

Contraindications

Use with deep, open, or profusely bleeding wounds

Warnings/Precautions

Concerns related to adverse effects:

• Skin irritation: May sting upon application; discontinue use if redness or other signs of irritation occur.

Special populations:

• Isocyanate sensitization: Patients sensitized to isocyanate should not use poly-ureaurethane.

Other warnings/precautions:

• Flammable: Formulation is flammable; do not expose to high temperatures or near open flame. Use in a well-ventilated area.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, topical:

Nuvail™: 16% (15 mL)

Generic Equivalent Available: US

No

Administration: Adult

Apply evenly to affected nail plate, proximal and lateral folds, and distal tip; allow to dry completely. Clean affected nails with nail polish remover once weekly. Use of other topical products before application of poly-ureaurethane may prevent film formation and reduce effectiveness. To avoid staining, avoid contact with finished surfaces (eg, furniture, counter tops).

Use: Labeled Indications

Nail dystrophy: Management of signs and symptoms of nail dystrophy such as nail splitting and nail fragility for intact or damaged nails.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Mechanism of Action

Biocompatible, polymeric solution; forms uniform film that protects nail from abrasion, friction, and moisture

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AU) Australia: Restoranail;
  • (NZ) New Zealand: Restoranail;
  • (PR) Puerto Rico: Nuvail;
  • (SG) Singapore: Restoranail
  1. Nuvail bandage, liquid (poly-ureaurethane) [prescribing information]. Charleston, SC: EPI Health LLC; June 2017.
Topic 87298 Version 29.0

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