Version May 2024
| Adverse event | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
| Hypertension | Adult: Systolic BP 120 to 139 mmHg or diastolic BP 80 to 89 mmHg Pediatric: Systolic/diastolic BP >90th percentile but <95th percentile Adolescent: BP ≥120/80 even if <95th percentile | Adult: Systolic BP 140 to 159 mmHg or diastolic BP 90 to 99 mmHg if previously WNL; change in baseline medical intervention indicated; recurrent or persistent (≥24 hours); symptomatic increase by >20 mmHg (diastolic) or to >140/90 mmHg; monotherapy indicated or initiated Pediatric and adolescent: Recurrent or persistent (≥24 hours) BP >ULN; monotherapy indicated; systolic and/or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile Adolescent: Systolic between 130 to 139 or diastolic between 80 to 89 even if <95th percentile | Adult: Systolic BP ≥160 mmHg or diastolic BP ≥100 mmHg; medical intervention indicated; more than one drug or more intensive therapy than previously used indicated Pediatric and adolescent: Systolic and/or diastolic >5 mmHg above the 99th percentile | Adult and pediatric: Life-threatening consequences (eg, malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated | Death |
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