Version May 2024
| Polysaccharide vaccine | Conjugate polysaccharide vaccine | |
| Stimulates antibodies in infants and toddlers | No | Yes |
| Stimulates antibodies in healthy adults | Yes | Yes |
| Stimulates antibodies in immunocompromised adults | +/- | +/- |
| Antibodies are long-lasting | +/- | +/- |
| Primes immunologically for enhanced responses | No | Possibly |
| Stimulates mucosal immunity, resulting in decreased colonization | No | Yes |
| Exhibits herd effect (secondary protection of unvaccinated individuals) | No | Yes |
| Use is associated with replacement strains | No | Yes |
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