Clinical and genomic features of medulloblastoma groups*

WNT: Wingless-related integration site; SHH: sonic hedgehog; LCA: large cell and anaplastic; MBEN: medulloblastoma with extensive nodularity; CGNPs: cerebellar granule neuron precursors; EGL: external granule cell layer; SVZ: subventricular zone; CTNNB1: β-catenin; DDX3X: DEAD-box helicase 3 X-linked; SMARCA4: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; MLL: mixed lineage leukemia; TP53: tumor protein p53; PTCH1: patched 1; BCOR: BCL6 co-repressor; LDB1: LIM domain binding 1; TCF4: transcription factor 4; GLI2: GLI family zinc finger 2; OTX2: orthodenticle homeobox 2; CTDNEP1: CTD nuclear envelope phosphatase 1; LRP1B: low density lipoprotein receptor-related protein 1B; KDM6A: lysine-specific demethylase 6A; SNCAIP: α-synuclein interacting protein; CDK6: cyclin-dependent kinase 6; ZMYM3: zinc finger MYM-type containing 3; SCNA: somatic copy number aberration.

* Group frequency, demographics, clinical features, and cytogenetic profiles were derived from a cohort of 827 medulloblastomas distributed into subgroups described by Northcott, et al (2012).