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Emedastine (United States: Not available): Drug information

Emedastine (United States: Not available): Drug information
(For additional information see "Emedastine (United States: Not available): Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Pharmacologic Category
  • Histamine H1 Antagonist;
  • Histamine H1 Antagonist, Second Generation
Dosing: Adult
Allergic conjunctivitis

Allergic conjunctivitis: Ophthalmic: Instill 1 drop in affected eye up to 4 times daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric
Allergic conjunctivitis

Allergic conjunctivitis: Children ≥3 years and Adolescents: Refer to adult dosing.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Frequency not always defined.

>10%: Central nervous system: Headache (11%)

1% to 10%:

Cardiovascular: Hyperemia

Central nervous system: Abnormal dreams

Dermatologic: Dermatitis, pruritus

Gastrointestinal: Dysgeusia

Neuromuscular & skeletal: Weakness

Ophthalmic: Blurred vision, corneal infiltrates, corneal staining, keratitis, lacrimation, transient burning or stinging in the eyes, xerophthalmia

Respiratory: Rhinitis, sinusitis

Contraindications

Hypersensitivity to emedastine or any component of the formulation

Warnings/Precautions

Special populations:

• Contact lens wearers: Contains benzalkonium chloride which may be absorbed by soft contact lenses; remove contact lenses prior to use and wait ≥10 minutes before reinserting.

Other warnings/precautions:

• Appropriate use: For topical ophthalmic use only. Do not wear contact lens if eye is red; not for the treatment of contact lens irritation. To avoid contamination, do not touch dropper tip to eyelids or other surfaces when placing drops in eyes.

Generic Equivalent Available: US

May be product dependent

Pricing: US

Solution (Emadine Ophthalmic)

0.05% (per mL): $31.84

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Ophthalmic: For topical ophthalmic use only, not for injection. Wash hands before use. To avoid contamination, do not touch dropper tip to eyelids or other surfaces when placing drops in eyes. Remove contact lenses prior to administration. Wait ≥10 minutes before reinserting lenses. Do not wear contact lenses if eyes are red.

Administration: Pediatric

Ophthalmic: For topical ophthalmic use only, not for injection. Wash hands before use. Remove contact lenses prior to administration. Wait ≥10 minutes following emedastine instillation before reinserting lenses. Do not wear contact lenses if eyes are red. To avoid contamination, do not touch dropper tip to eyelids or other surfaces when placing drops in eyes.

Use: Labeled Indications

Allergic conjunctivitis: For the temporary relief of the signs and symptoms of allergic conjunctivitis

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Adverse events have not been observed in animal reproduction studies. Systemic absorption is limited following ocular administration. Use during pregnancy is not expected to result in significant exposure to the fetus.

Breastfeeding Considerations

It is not known if emedastine is excreted in breast milk. The manufacturer recommends that caution be exercised when administering emedastine to nursing women.

Mechanism of Action

Selective histamine H1-receptor antagonist for topical ophthalmic use

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Ocular: Minimal

Half-life elimination: Oral: Plasma: 3 to 4 hours

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Emadine;
  • (AT) Austria: Emadine;
  • (BD) Bangladesh: Emadine;
  • (BE) Belgium: Emadine;
  • (BG) Bulgaria: Emadine;
  • (BR) Brazil: Emadine;
  • (CH) Switzerland: Emadine SE;
  • (CN) China: Emadine;
  • (CZ) Czech Republic: Emadine;
  • (DE) Germany: Emadine;
  • (DO) Dominican Republic: Emadine;
  • (EE) Estonia: Emadine;
  • (EG) Egypt: Emadine;
  • (ES) Spain: Emadine;
  • (FI) Finland: Emadine;
  • (FR) France: Emadine;
  • (GB) United Kingdom: Emadine;
  • (GR) Greece: Emadine;
  • (HK) Hong Kong: Emadine;
  • (HU) Hungary: Emadine;
  • (IE) Ireland: Emadine;
  • (IL) Israel: Emadine;
  • (IT) Italy: Emadine;
  • (JO) Jordan: Emadine;
  • (KE) Kenya: Emadine;
  • (KR) Korea, Republic of: Emadine;
  • (KW) Kuwait: Emadine;
  • (LB) Lebanon: Emadine;
  • (LT) Lithuania: Emadine;
  • (LU) Luxembourg: Emadine;
  • (LV) Latvia: Emadine;
  • (MA) Morocco: Emadine;
  • (MY) Malaysia: Emadine;
  • (NL) Netherlands: Emadine;
  • (NO) Norway: Emadine;
  • (PK) Pakistan: Emadine;
  • (PL) Poland: Emadine;
  • (PR) Puerto Rico: Emadine;
  • (PT) Portugal: Emadine;
  • (RO) Romania: Emadine;
  • (SA) Saudi Arabia: Emadine;
  • (SE) Sweden: Emadine;
  • (SI) Slovenia: Emadine;
  • (SK) Slovakia: Emadine;
  • (TH) Thailand: Emadine;
  • (TN) Tunisia: Emadine;
  • (TR) Turkey: Emadine | Emeksat;
  • (TW) Taiwan: Emadine | Ementin;
  • (UA) Ukraine: Emadin;
  • (UY) Uruguay: Emadine;
  • (ZA) South Africa: Emadine
  1. Emadine (emedastine) [prescribing information]. Fort Worth, TX: Alcon Laboratories Inc; May 2009.
Topic 8778 Version 252.0

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