Table showing the risk of HUS recurrence according to genetic mutation

Gene	Protein location	Functional impact	Mutation frequency in aHUS (percent)	Recurrence frequency after transplantation (percent)
Mutation
CFH	Plasma	Loss	20-30	75-90
CFI	Plasma	Loss	2-12	45-80
CFB	Plasma	Gain	1-2	100
C3	Plasma	Gain	5-10	40-70
MCP	Membrane	Loss	10-15	15-20
THBD	Membrane	Loss	5	1 case
Genetic polymorphism (frequency in control populations)
Homozygous CFHR1del (3 to 8 percent)	Circulating	Undetermined	14-23 (>90 percent in patients with anti-CFH antibodies)	NA

aHUS: atypical hemolytic uremic syndrome; CFH/I/B: complement factor H/I/B; C3: complement C3; MCP: membrane cofactor protein; THBD: thrombomodulin; NA: not available.

Reprinted by permission from: Macmillan Publishers Ltd: Nature Reviews Nephrology. Zuber J, Le Quintrec M, Sberro-Soussan R, et al. New insights into postrenal transplant hemolytic uremic syndrome. Nat Rev Nephrol 2011; 7:23. Copyright © 2011. www.nature.com/nrneph.

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Table showing the risk of HUS recurrence according to genetic mutation