Pathological findings in Balamuthia mandrillaris amebic infection

(Panel A) At scanning magnification, a pattern of ill-defined granulomas occupying the reticular dermis (hematoxylin and eosin [H&E], x40).
(Panel B) The granulomatous pattern is usually accompanied by the presence of multiple giant cells (H&E, x400).
(Panel C) A trophozoite with ample cytoplasm, round nucleus, and nucleolus (H&E, x1000).
(Panel D) A round trophozoite, with bubbly cytoplasm and eccentric located nucleus (H&E, x1000).