Pathologic findings in granulomatous amebic encephalitis (GAE)

(Panel A) A case of GAE, showing numerous trophozoites surrounding a blood vessel. Notice the prominent karyosome in most organisms and the cytoplasmic vacuole in a few parasites. Hematoxylin and eosin, x160.
(Panel B) Multiple amebic trophozoites surrounding a blood vessel in a case of GAE caused by Balamuthia mandrillaris. Periodic acid-Schiff, x160.