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خرید پکیج
تعداد آیتم قابل مشاهده باقیمانده : 3 مورد
نسخه الکترونیک
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Panel of routine immunohistochemical markers for the evaluation of suspected anaplastic thyroid cancer and expected results compared with other tumor types

Panel of routine immunohistochemical markers for the evaluation of suspected anaplastic thyroid cancer and expected results compared with other tumor types
IHC marker DTC PDTC ATC MTC SCC Lymphoma
Pan-cytokeratins +++ +++ +++/– +++ +++ –
Thyroglobulin +++ +/– – – – –
Thyroid-transcription factor 1 +++ +/– –/+ +/– – –
BRAFV600E +/– –/+ –/+ – – –
PAX8 +++ +++ +/– +/– – +/–*
Ki-67 <5% 5 to 30% >30% <20% >30% Variable
Chromogranin – – – +++ – –
Calcitonin – – – +++/– – –
Carcinoembryonic antigen – – – +++ – –
p53 – (rare +) –/+ +/– – +/– +/–
CD45, other lymphoid markers – – – – – +++
IHC: immunohistochemistry; DTC: differentiated thyroid cancer; PDTC: poorly differentiated thyroid cancer; ATC: anaplastic thyroid cancer; MTC: medullary thyroid cancer; SCC: squamous cell carcinoma; +: relative positive staining; –: negative staining; +/–: variable positivity.
* PAX8 antibodies can crossreact with PAX5, which is expressed in lymphoid cells.
¶ Percentage of nuclei positive for Ki-67.
Reproduced with permission from: Bible KC, Kebebew E, Brierley J, et al. 2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer. Thyroid 2021; 31: 337. Copyright © 2021 Mary Ann Liebert, Inc. The publisher for this copyrighted material is Mary Ann Liebert, Inc. publishers.
Graphic 88072 Version 4.0

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