Frequency of extraintestinal manifestations in pediatric patients with inflammatory bowel disease

	Total n (percent)	Crohn disease n (percent)	Ulcerative colitis n (percent)
Total	1009	728	281
Any extraintestinal manifestation*	285 (28.2%)	218 (29.9%)	67 (23.8%)
Arthralgia	166 (16.5%)	124 (17%)	42 (14.9%)
Aphthous stomatitis	81 (8%)	72 (9.9%)^¶	9 (3.2%)^¶
Arthritis	37 (3.7%)	32 (4.4%)	5 (1.8%)
Erythema nodosum	28 (2.8%)	26 (3.6%)^Δ	2 (0.71%)^Δ
Primary sclerosing cholangitis	15 (1.5%)	7 (1%)^◊	8 (2.8%)^◊^§
Pancreatitis	9 (0.9%)	5 (0.7%)	4 (1.4%)
Chronic active hepatitis	6 (0.6%)	2 (0.3%)	4 (1.4%)
Iritis or uveitis	7 (0.7%)	6 (0.8%)	1 (0.4%)
Ankylosing spondylitis	4 (0.4%)	4 (0.5%)	0
Pyoderma gangrenosum	3 (0.3%)	3 (0.4%)	0

Fever and fatigue are also common in inflammatory bowel disease but were not specifically tracked in this study.

* Number of individual subjects with one or more extraintestinal manifestations.
¶ p<0.001 for Crohn disease versus ulcerative colitis.
Δ p<0.01 for Crohn disease versus ulcerative colitis.
◊ p = 0.039 for Crohn disease versus ulcerative colitis.
§ The prevalence of primary sclerosing cholangitis may be as high as 10% among pediatric patients with ulcerative colitis, according to a study using rigorous case-finding methods^[1].

Reference:

Deneau M, Jensen MK, Holmen J, et al. Primary sclerosing cholangitis, autoimmune hepatitis and overlap in Utah children: Epidemiology and natural history. Hepatology 2013.

Reproduced with permission from: Dotson JL, Hyams JS, Markowitz J, et al. Extraintestinal manifestations of pediatric inflammatory bowel disease and their relation to disease type and severity. J Pediatr Gastroenterol Nutr 2010; 51:140. DOI: 10.1097/MPG.0b013e3181ca4db4. Copyright © 2010 ESPGHAN and NASPGHAN. Unauthorized reproduction of this material is prohibited.

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Frequency of extraintestinal manifestations in pediatric patients with inflammatory bowel disease