Version May 2024
Cold sores, pruritus/pain, infection: Topical: Apply small amount to affected area 1 to 3 times/day.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely because of low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely because of low systemic absorption.
Refer to adult dosing.
(For additional information see "Camphor and phenol: Pediatric drug information")
Note: Not for oral ingestion; severe, potentially fatal adverse reactions have been reported with ingestion (Ref).
Cold sores (treatment), pruritus/pain (treatment), infection (prevention): Children ≥2 years and Adolescents: Topical: Apply a small amount to affected area 1 to 3 times daily.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely because of low systemic absorption.
There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely because of low systemic absorption.
There are no adverse reactions listed in the manufacturer's labeling.
OTC labeling: When used for self-medication, do not use over large areas of the body or with a bandage.
Special populations:
• Pediatric: The American Academy of Pediatrics suggests that camphor be avoided in pediatric patients because of its lack of efficacy and the well-documented toxicity that may occur with use (AAP 1994). Although toxicity most often results from oral ingestion of topical or inhalation products, combined dermal and inhalation exposure has resulted in toxicity (Love 2004).
Other warnings/precautions:
• Appropriate use: For external use only; avoid contact with eyes.
• Self-medication (OTC use): When used for self-medication (OTC use), do not use on deep puncture wounds, animal bites, serious burns, or for >7 days. Consult health care provider if condition worsens or gets better and returns after a few days.
Camphor may cause significant and potentially life-threatening adverse effects in children; most reported cases are with accidental oral ingestions; however, toxicity has also been reported with topical application in an infant. Mild toxicity may cause GI effects (eg, nausea, vomiting) or burning sensation; however, severe effects such as restlessness, delirium, seizures, and fatal respiratory depression possibly leading to death can occur with doses as low as 500 mg. Onset of toxicity can occur as rapidly as 5 to 15 minutes after ingestion. Adults appear to be able to tolerate higher ingestions; however, oral ingestion is not recommended (AAP 1994; Khine 2009; Love 2004; Manoguerra 2006; Mathen 2018). Due to the increased potential for toxicity, the limited beneficial effects of camphor, and the availability of safer alternative agents for all approved camphor uses, experts recommend camphor should be used with extreme caution, if at all, in pediatric patients (AAP 1994; Love 2004; PPA [Meyers 2020]).
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Gel, External:
Campho Phenique Maximum St: Camphor 10.8% and phenol 4.7% (14 g)
Campho-Phenique: Camphor 10.8% and phenol 4.7% (6.5 g [DSC], 14 g [DSC])
Campho-Phenique Cold Sore: Camphor 10.8% and phenol 4.7% (6.5 g)
Liquid, External:
Campho Phenique Maximum St: Camphor 10.8% and phenol 4.7% (22 mL)
Campho-Phenique: Camphor 10.8% and phenol 4.7% (22 mL [DSC], 45 mL [DSC])
No
Gel (Campho-Phenique External)
10.8-4.7% (per gram): $0.59
Liquid (Campho-Phenique External)
10.8-4.7% (per mL): $0.15
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Topical: Clean affected area prior to use; do not cover with bandage.
Topical: For external use only; avoid contact with eyes. Clean affected area prior to use; do not cover with bandage. Do not apply to large areas of the body.
Cold sores: Temporary relief of pain and itching associated with cold sores and fever blisters.
Infection: Prevention of infection in cold sores, minor cuts, scrapes, and burns.
Pruritus/pain: Relief of pain and itching associated with minor burns, sunburn, minor cuts, insect bites, scrapes, and minor skin irritation.
KIDs List: Camphor, when used in pediatric patients <18 years of age, is identified on the Key Potentially Inappropriate Drugs in Pediatrics (KIDs) list and should be used with caution due to risk of seizures (weak recommendation; low quality of evidence) (PPA [Meyers 2020]).
None known.
There are no known significant interactions.
Refer to individual monographs.
Refer to individual monographs.
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