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Cetylpyridinium: Drug information

Cetylpyridinium: Drug information
(For additional information see "Cetylpyridinium: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Cepacol Antibacterial [OTC];
  • Clean Zing [OTC] [DSC];
  • GoodSense Oral Rinse [OTC];
  • Larynex [OTC] [DSC]
Pharmacologic Category
  • Antiseptic, Oral Mouthwash
Dosing: Adult
Antiseptic

Antiseptic (OTC labeling): Oral: Swish 20 mL thoroughly between teeth for 30 seconds then spit; use twice daily; may be used before or after brushing; do not swallow.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric
Antiseptic

Antiseptic (OTC labeling): Children ≥6 years: Refer to adult dosing.

Adverse Reactions

There are no adverse reactions listed in the manufacturer's labeling.

Postmarketing: Hypersensitivity: Type 1 hypersensitivity reaction (Shima 2015)

Contraindications

Hypersensitivity to cetylpyridinium or any component of the formulation

Warnings/Precautions

Other warnings/precautions:

• Accidental ingestion: If an amount greater than used for rinsing is swallowed, seek professional assistance or contact a poison control center immediately.

• Self-medication (OTC use): Stop use and consult a healthcare professional if symptoms or condition worsening or persists; if gingivitis, bleeding, or redness persists for more than 2 weeks; if gums are painful and swollen; if pus from the gum line, loose teeth, or increased spacing between the teeth occurs. Avoid contact with eyes.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Liquid, Mouth/Throat, as chloride:

Cepacol Antibacterial: 0.05% (710 mL) [contains alcohol, usp, edetate (edta) disodium, fd&c yellow #5 (tartrazine), menthol, polysorbate 80, saccharin sodium]

Clean Zing: 0.06% (480 mL [DSC]) [alcohol free, no artificial color(s); contains sodium benzoate]

GoodSense Oral Rinse: 0.07% (1000 mL) [alcohol free; contains fd&c blue #1 (brilliant blue), methylparaben, propylene glycol, propylparaben, saccharin sodium]

Lozenge, Mouth/Throat, as chloride:

Larynex: (500 ea [DSC])

Generic Equivalent Available: US

Yes

Pricing: US

Liquid (Cepacol Antibacterial Mouth/Throat)

0.05% (per mL): $0.01

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Administration: Adult

Vigorously swish between teeth; do not swallow.

Administration: Pediatric

Oral: Vigorously swish between teeth; do not swallow. Supervise use in children 6 to <12 years of age.

Use: Labeled Indications

Antiseptic to aid in the prevention and reduction of plaque and gingivitis, and to freshen breath

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Cetylpyridinium chloride mouthwash (alcohol free) has been associated with a reduction in preterm births in pregnant women with periodontal disease (Jeffcoat, 2011).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AT) Austria: Dobendan | Dobendan Sugar free | Halset;
  • (AU) Australia: Lemsip Sore Throat Antibacterial;
  • (BR) Brazil: Cepacol | Gargocetil | Gargomax;
  • (CH) Switzerland: Halset;
  • (CO) Colombia: Cepacol;
  • (CZ) Czech Republic: Halset;
  • (DE) Germany: Akute Hals- u. Rachenhilfe | Bad Heilbrunner Hals | Dobendan | Dobendan strepsils mint | Dobendan Strepsils Zuckerfrei | Dobendan x | Frubizin;
  • (EE) Estonia: Septolete apple | Septolete cherry | Septolete lemon;
  • (GB) United Kingdom: Contac | Merocets;
  • (HK) Hong Kong: Cepacol;
  • (HU) Hungary: Halset;
  • (IE) Ireland: Merocets;
  • (IN) India: Kolq;
  • (IT) Italy: Algol | Borocaina gola | Cetilsan | Farin gola | Golafair | Honeygola | Neo cepacol | Neo coricidin gola | Neo formitrol;
  • (JP) Japan: Benza ace | Ice troche | Pitas | Suprol | Vicks;
  • (KR) Korea, Republic of: Cegaton | Coolmed | Coolstak | Sensecool;
  • (MX) Mexico: Cepacol;
  • (MY) Malaysia: Avosil;
  • (NZ) New Zealand: Cepacol;
  • (PE) Peru: Cepacol;
  • (PL) Poland: Halset | Menthosept | Septolete apple | Septolete cherry | Septolete junior | Septolete lemon;
  • (RO) Romania: Septolete apple;
  • (RU) Russian Federation: Septolete neo;
  • (SG) Singapore: Cepacol;
  • (SI) Slovenia: Halset;
  • (SK) Slovakia: Neoseptolete;
  • (TH) Thailand: Hops | Orasept;
  • (TR) Turkey: Penipastil;
  • (TW) Taiwan: C.p.c. | Cero | Cetylpyridinium | Cleanthroat | Colgen | Earsun sore throat | Hoshipei | Hosoon | Ja Ja | Kodesmin | Liho | Liue | Pabulon | Secola | Shodin | Souriree Suango | Su-Ho | Sucin | Suthroat | Suyi sore | Throzen | Trogin;
  • (VE) Venezuela, Bolivarian Republic of: Cepacol;
  • (ZA) South Africa: Cepacol | Septolete;
  • (ZM) Zambia: Cetylpyridinium
  1. Cepacol Antibacterial (cetylpyridinium chloride) [prescribing information]. Parsippany, NJ: Reckitt Benckiser; received May 2020.
  2. Jeffcoat M, Parry S, Gerlach RW, et al, "Use of Alcohol-Free Antimicrobial Mouth Rinse Is Associated With Decreased Incidence of Preterm Birth in a High-Risk Population," Am J Obstet Gynecol, 2011, 205(4):382.e1-6. [PubMed 22083060]
  3. Shima K, Tanizaki H, Endo Y, et al. Immediate hypersensitivity caused by cetylpyridinium chloride in a throat spray. Contact Dermatitis. 2015;73(4):248-249. doi:10.1111/cod.12418 [PubMed 25982052]
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