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Absorbable collagen (dental): Drug information

Absorbable collagen (dental): Drug information
For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • HeliCote;
  • HeliPlug;
  • HeliTape;
  • Zimmer Collagen Patch;
  • Zimmer Collagen Plug;
  • Zimmer Collagen Tape
Pharmacologic Category
  • Hemostatic Agent
Dosing: Adult
Control of bleeding

Control of bleeding: Topical: A sufficiently large dressing should be selected so as to completely cover the oral wound.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

Refer to adult dosing.

Adverse Reactions

The following adverse drug reactions are derived from product labeling unless otherwise specified. Reactions listed are based on reports for other agents in this same pharmacologic class and may not be specifically reported for collagen (absorbable/dental).

Frequency not defined:

Hypersensitivity: Hypersensitivity reaction

Nervous system: Foreign body reaction

Miscellaneous: Seroma (subgaleal)

Contraindications

There are no contraindications listed in the manufacturer’s labeling.

Warnings/Precautions

Other warnings/precautions:

• Appropriate use: Should not be used on infected or contaminated wounds.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Wound dressing:

3/8” x 3/4

3/4” x 1 1/2

1” x 3”

Generic Equivalent Available: US

Yes

Administration: Adult

Topical: Rinse the oral wound or sore and remove excessive fluid; apply a dressing sufficiently large to completely cover the oral wound or sore and hold in place with moderate pressure. The time necessary to apply pressure will vary with the degree of bleeding. In general, 2 to 5 minutes should be sufficient to achieve hemostasis. Refer to manufacturer's labeling for additional product-specific instructions.

Administration: Pediatric

Topical: Rinse the oral wound or sore and remove excessive fluid; apply a dressing sufficiently large to completely cover the oral wound or sore and hold in place with moderate pressure. The time necessary to apply pressure will vary with the degree of bleeding. In general, 2 to 5 minutes should be sufficient to achieve hemostasis.

Use: Labeled Indications

Hemostatic: Application to moist or bleeding clean oral wounds created during dental surgery, to control bleeding and protect the surface of the wound from further injury.

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Mechanism of Action

The highly porous sponge structure absorbs blood and wound exudate. The collagen component causes aggregation of platelets which bind to collagen fibrils. The aggregated platelets degranulate, releasing coagulation factors that promote the formation of fibrin.

  1. HeliTape, HeliCote, HeliPlug (collagen [absorbable]) [prescribing information]. York, PA: Miltex, Inc; July 2007.
  2. Zimmer Collagen Plug, Tape, Patch (collagen [absorbable]) [prescribing information]. Palm Beach Gardens, FL: Zimmer Biomet Dental; March 2020.
Topic 8882 Version 63.0

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