Prevalence of clinical signs during malignant hyperthermia episode

Clinical sign	Percentage with sign
Hypercarbia	92.2
Sinus tachycardia	72.9
Rapidly increasing temperature	64.7
Elevated temperature	52.2
Generalized muscular rigidity	40.8
Tachypnea	27.1
Masseter spasm	26.7
Sweating	17.6
Cola-colored urine	13.7
Cyanosis	9.4
Ventricular tachycardia	3.5
Excessive bleeding	2.7
Ventricular fibrillation	2.4

Clinical signs of malignant hyperthermia, listed with the prevalence with which each was noted in 255 patients reported to the North American MH Registry from 1987 to 2006. Signs such as hypercarbia and tachycardia were defined as being inappropriate to the clinical situation. Notably, 79.6 percent had one or more signs indicative of muscular involvement (masseter spasm, generalized muscular rigidity, cola-colored urine, peak creatinine kinase >10,000 units/L, or peak potassium >6.0 mEq/L).

Data from: Larach MG, Gronert GA, Allen GC, et al. Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006. Anesth Analg 2010; 110:498.

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Prevalence of clinical signs during malignant hyperthermia episode