Version July 2025
Anesthesia, topical: Topical:
Minor surgical procedures; pre-injection anesthesia: Spray affected area continuously for 3 to 7 seconds (amber bottle) or 4 to 10 seconds (aerosol) from a distance of 3 to 9 inches; spray until skin just turns white.
Myofascial pain (spray and stretch technique): Spray affected area in parallel sweeps of 0.5 to 1 inch apart at a rate of 4 inches (10 cm)/second at a distance of 12 to 18 inches while passively stretching muscle; number of sweeps determined by size of muscle.
Relief of minor sports injuries: Dosage varies with duration of application; use smallest effective dose. Spray affected area continuously for 3 to 7 seconds (amber bottle) or 4 to 10 seconds (aerosol) from a distance of 3 to 9 inches; spray until skin just turns white.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
Refer to adult dosing.
Anesthesia, topical: Topical: Refer to adult dosing.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no dosage adjustments provided in the manufacturer's labeling.
There are no adverse reactions listed in the manufacturer's labeling.
Hypersensitivity to ethyl chloride or any component of the formulation
Concerns related to adverse effects:
• Cutaneous sensitization: Rarely, cutaneous sensitization may occur. Frostbite and/or altered skin pigmentation may occur with excess application.
Other warnings/precautions:
• Appropriate use: For topical use only. Do not spray into eyes; avoid inhalation.
• Flammable: Formulation is flammable; avoid use near open flame or electrical cautery equipment. Do not place on hot surfaces.
Excipient information presented when available (limited, particularly for generics); consult specific product labeling.
Aerosol, External:
Generic: 100% (105 mL, 116 mL)
Yes
For topical use only; avoid spraying in eyes and inhalation. Before applying open amber bottle dispenser spring valve completely and invert to spray; keep aerosol can upright while spraying. Avoid prolonged spraying of skin to avoid frosting of the skin. When used for local freezing of tissues, apply petrolatum to adjacent skin areas for protection. When used for myofascial pain, apply moist heat for 10 to 15 minutes following administration.
Topical: For topical use only; avoid spraying in eyes and inhalation. Before applying, open amber bottle dispenser spring valve completely and invert to spray; keep aerosol can upright while spraying. Spray for a few seconds (in general, 3 to 7 seconds from amber bottle and 4 to 10 seconds from aerosol) until the tissue becomes white; avoid prolonged spraying of skin to avoid frosting of the skin. When used for local freezing of tissues, apply petroleum to adjacent skin areas for protection. When used for myofascial pain, apply moist heat for 10 to 15 minutes following administration.
Anesthesia, topical: Control pain associated with injections, starting IV lines, venipuncture, and minor surgical procedures, including lancing boils and drainage of small abscesses; temporary relief of pain caused by minor sport injury; treatment of myofascial pain caused by trigger points, restricted motion, and muscle tension.
None known.
Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the drug interactions program by clicking on the “Launch drug interactions program” link above.
Articaine: May increase adverse/toxic effects of Local Anesthetics. Risk C: Monitor
Methemoglobinemia Associated Agents: May increase adverse/toxic effects of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor
ROPivacaine: May increase adverse/toxic effects of Local Anesthetics. Risk C: Monitor
Skin absorption may occur; the amount of ethyl chloride available systemically is unknown.
Duration: A few seconds to 1 minute
